Evaluation of the cytotoxic profile of CD4 + T cells in the spontaneous autoimmune diabetes model in NOD (non obese diabetic) mice
Type 1 Diabetes Mellitus is an autoimmune disease characterized by the destruction of the pancreatic beta cells by the action of autoreactive T cells. Using Non Obese Diabetic (NOD) mice, expression of cytotoxicity-related molecules on CD4 + helper T cells in the pancreas and peripancreatic lymph no...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/1048 |
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| author | Bonora Júnior, Maurílio Farias, Alessandro dos Santos Rovarotto, Carolina Francelin Pradela, Fernando |
| author_facet | Bonora Júnior, Maurílio Farias, Alessandro dos Santos Rovarotto, Carolina Francelin Pradela, Fernando |
| author_sort | Bonora Júnior, Maurílio |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | Type 1 Diabetes Mellitus is an autoimmune disease characterized by the destruction of the pancreatic beta cells by the action of autoreactive T cells. Using Non Obese Diabetic (NOD) mice, expression of cytotoxicity-related molecules on CD4 + helper T cells in the pancreas and peripancreatic lymph node of diabetic animals was observed. However, unlike what has been seen in the EAE model, the expression of one of the major cytotoxic molecules is similar in both organs, while two others express much more in the target organ of diabetes than in the draining lymph node. |
| first_indexed | 2025-10-08T13:52:55Z |
| format | Online |
| id | ojs-article-1048 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:52:55Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-10482025-09-26T14:32:30Z Evaluation of the cytotoxic profile of CD4 + T cells in the spontaneous autoimmune diabetes model in NOD (non obese diabetic) mice Bonora Júnior, Maurílio Farias, Alessandro dos Santos Rovarotto, Carolina Francelin Pradela, Fernando Diabetes type 1 T CD4 Cell Cytotoxicity. Type 1 Diabetes Mellitus is an autoimmune disease characterized by the destruction of the pancreatic beta cells by the action of autoreactive T cells. Using Non Obese Diabetic (NOD) mice, expression of cytotoxicity-related molecules on CD4 + helper T cells in the pancreas and peripancreatic lymph node of diabetic animals was observed. However, unlike what has been seen in the EAE model, the expression of one of the major cytotoxic molecules is similar in both organs, while two others express much more in the target organ of diabetes than in the draining lymph node. Universidade Estadual de Campinas 2019-02-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/1048 10.20396/revpibic2620181048 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/1048/1119 Copyright (c) 2019 Maurílio Bonora Júnior, Alessandro dos Santos Farias http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Bonora Júnior, Maurílio Farias, Alessandro dos Santos Rovarotto, Carolina Francelin Pradela, Fernando Diabetes type 1 T CD4 Cell Cytotoxicity. Evaluation of the cytotoxic profile of CD4 + T cells in the spontaneous autoimmune diabetes model in NOD (non obese diabetic) mice |
| title | Evaluation of the cytotoxic profile of CD4 + T cells in the spontaneous autoimmune diabetes model in NOD (non obese diabetic) mice |
| title_full | Evaluation of the cytotoxic profile of CD4 + T cells in the spontaneous autoimmune diabetes model in NOD (non obese diabetic) mice |
| title_fullStr | Evaluation of the cytotoxic profile of CD4 + T cells in the spontaneous autoimmune diabetes model in NOD (non obese diabetic) mice |
| title_full_unstemmed | Evaluation of the cytotoxic profile of CD4 + T cells in the spontaneous autoimmune diabetes model in NOD (non obese diabetic) mice |
| title_short | Evaluation of the cytotoxic profile of CD4 + T cells in the spontaneous autoimmune diabetes model in NOD (non obese diabetic) mice |
| title_sort | evaluation of the cytotoxic profile of cd4 + t cells in the spontaneous autoimmune diabetes model in nod (non obese diabetic) mice |
| topic | Diabetes type 1 T CD4 Cell Cytotoxicity. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/1048 |
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