Nanostructured lipid carriers with ultra purified lipids for sustained release of intravenous lidocaine
Lidocaine (LDC) is a local anesthetic that can be used for post-surgical or cancer related pain, via intravenous infusion or bolus. An alternative to maintain drug plasma levels are the sustained release carriers, whereas nanostructured lipid carriers (NLCs) stand out; they have biocompatibility, lo...
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| Main Authors: | , , |
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| Format: | Online |
| Language: | Portuguese |
| Published: |
Universidade Estadual de Campinas
2018
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| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/110 |
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| Summary: | Lidocaine (LDC) is a local anesthetic that can be used for post-surgical or cancer related pain, via intravenous infusion or bolus. An alternative to maintain drug plasma levels are the sustained release carriers, whereas nanostructured lipid carriers (NLCs) stand out; they have biocompatibility, low toxicity, reproducibility and high efficiency in the transport of hydrophobic drugs.This work aims to study the solubility parameter of the LDC pre formulation in several ultra-purified lipids, compatible with the endovenous route, and to formulate NLCs based on these lipids for LDC encapsulation. |
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| ISSN: | 2596-1969 |
