Towards the total synthesis of the labdane diterpenes Cacofurans A and B
Cacospongia sp. is a species of marine sponge that produces labdane-class diterpens known as Cacofurans A and B, which show cytotoxic activity in vitro. In this work, we present the synthetic pathway of Cacofurans A and B in ten and nine steps, respectively. Five steps of the synthetic proposal were...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Universidade Estadual de Campinas
2019
|
| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/1144 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Cacospongia sp. is a species of marine sponge that produces labdane-class diterpens known as Cacofurans A and B, which show cytotoxic activity in vitro. In this work, we present the synthetic pathway of Cacofurans A and B in ten and nine steps, respectively. Five steps of the synthetic proposal were completed, with 25% overall yield, including the formation of a five-membered ring using the Suárez reaction. After the completion of the total synthesis, the cytotoxic potential of Cacofurans A and B will be evaluated. |
|---|---|
| ISSN: | 2596-1969 |
