Structural hypothalamic abnormalities in amyotrophic lateral sclerosis (ALS)
ALS is a disease that progressively affects the upper and lower motor neurons concomitantly. Early pronounced weight loss is a common symptom, which correlates with survival time. Our hypothesis is that this symptom originates from changes in the hypothalamus, which is essential in metabolic control...
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| Language: | English |
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Universidade Estadual de Campinas
2018
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/128 |
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| author | Hernández, Ana Luisa de Carvalho Cardozo Junior, Marcondes Cavalcante Franca Rezende, Thiago Junqueira Ribeiro de |
| author_facet | Hernández, Ana Luisa de Carvalho Cardozo Junior, Marcondes Cavalcante Franca Rezende, Thiago Junqueira Ribeiro de |
| author_sort | Hernández, Ana Luisa de Carvalho Cardozo |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | ALS is a disease that progressively affects the upper and lower motor neurons concomitantly. Early pronounced weight loss is a common symptom, which correlates with survival time. Our hypothesis is that this symptom originates from changes in the hypothalamus, which is essential in metabolic control. Therefore, the objective of this study was to determine if there are volumetric changes in the hypothalamus region, through the Multi-Atlas T1, in patients with ALS compared to a control group, and if there is correlation with clinical parameters.The mean ALSFRS score and disease duration were 32 and 3.8 years, respectively. ?In the volumetric analyses, there were no significant differences between patients and controls regarding Hypothalamus, Mammillary Body, Nucleus Accumbens , Anterior Basal Forebrain, and right-sided Posterior Basal Forebrain and Claustrum volumes. In contrast, we found left-sided Claustrum (p = 0.0002) and Posterior Basal Forebrain (p = 0.02) atrophy in the ALS group. There was no significant correlation between clinical parameters.Although there was no significant atrophy in the hypothalamus, nearby areas also involved in metabolic control were found abnormal in the patients. This reiterates the hypothesis that metabolic dysregulation is behind ALS-related cachexia. |
| first_indexed | 2025-10-08T13:49:33Z |
| format | Online |
| id | ojs-article-128 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:49:33Z |
| publishDate | 2018 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-1282025-09-26T14:32:30Z Structural hypothalamic abnormalities in amyotrophic lateral sclerosis (ALS) Hernández, Ana Luisa de Carvalho Cardozo Junior, Marcondes Cavalcante Franca Rezende, Thiago Junqueira Ribeiro de Amyotrophic Lateral Sclerosis Neuroimaging Metabolism. ALS is a disease that progressively affects the upper and lower motor neurons concomitantly. Early pronounced weight loss is a common symptom, which correlates with survival time. Our hypothesis is that this symptom originates from changes in the hypothalamus, which is essential in metabolic control. Therefore, the objective of this study was to determine if there are volumetric changes in the hypothalamus region, through the Multi-Atlas T1, in patients with ALS compared to a control group, and if there is correlation with clinical parameters.The mean ALSFRS score and disease duration were 32 and 3.8 years, respectively. ?In the volumetric analyses, there were no significant differences between patients and controls regarding Hypothalamus, Mammillary Body, Nucleus Accumbens , Anterior Basal Forebrain, and right-sided Posterior Basal Forebrain and Claustrum volumes. In contrast, we found left-sided Claustrum (p = 0.0002) and Posterior Basal Forebrain (p = 0.02) atrophy in the ALS group. There was no significant correlation between clinical parameters.Although there was no significant atrophy in the hypothalamus, nearby areas also involved in metabolic control were found abnormal in the patients. This reiterates the hypothesis that metabolic dysregulation is behind ALS-related cachexia. Universidade Estadual de Campinas 2018-12-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/128 10.20396/revpibic262018128 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/128/139 Copyright (c) 2018 Ana Luisa de Carvalho Cardozo Hernández, Marcondes Cavalcante Franca Junior http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Hernández, Ana Luisa de Carvalho Cardozo Junior, Marcondes Cavalcante Franca Rezende, Thiago Junqueira Ribeiro de Amyotrophic Lateral Sclerosis Neuroimaging Metabolism. Structural hypothalamic abnormalities in amyotrophic lateral sclerosis (ALS) |
| title | Structural hypothalamic abnormalities in amyotrophic lateral sclerosis (ALS) |
| title_full | Structural hypothalamic abnormalities in amyotrophic lateral sclerosis (ALS) |
| title_fullStr | Structural hypothalamic abnormalities in amyotrophic lateral sclerosis (ALS) |
| title_full_unstemmed | Structural hypothalamic abnormalities in amyotrophic lateral sclerosis (ALS) |
| title_short | Structural hypothalamic abnormalities in amyotrophic lateral sclerosis (ALS) |
| title_sort | structural hypothalamic abnormalities in amyotrophic lateral sclerosis (als) |
| topic | Amyotrophic Lateral Sclerosis Neuroimaging Metabolism. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/128 |
| work_keys_str_mv | AT hernandezanaluisadecarvalhocardozo structuralhypothalamicabnormalitiesinamyotrophiclateralsclerosisals AT juniormarcondescavalcantefranca structuralhypothalamicabnormalitiesinamyotrophiclateralsclerosisals AT rezendethiagojunqueiraribeirode structuralhypothalamicabnormalitiesinamyotrophiclateralsclerosisals |
