Genome editing of LKB1 (STK11) mutation in A549 lung cancer cells using CRISPR/Cas9 system

Mutations and deletions of the tumor suppressor LKB1 (STK11) are common in several malignancies, especially in non-small lung cancer cells (NSCLC). In that cell type, LKB1 inactivation coexists with mutations at other important cancer genes, including KRAS and TP53. The mutant LKB1 indirectly increa...

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Bibliographic Details

Main Authors:	Morelli, Ana Paula, Simabuco, Fernando Moreira, Pavan, Isadora Carolina B., Tavares, Mariana Rosolen, Salvino, Luiz Guilherme, Pereira, Nathalie F. P., Silva, Fernando Riback, Junior, Tharcisio Citrangulo Tortelli, Chammas, Roger
Format:	Online
Language:	English
Published:	Universidade Estadual de Campinas 2018
Subjects:	CRESPR/Cas9 LKB1 Lung Cancer.
Online Access:	https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/138
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