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Transcriptomic analysis of the subiculum region of the hippocampus in animals with temporal lobe epilepsy (ELTM) induced by pilocarpine

Mesial temporal lobe epilepsy (MTLE) is the most frequent type of epilepsy in adults and it is usually refractory to clinical treatments. In most patients with MTLE a characteristic histopathological lesion is observed, including hippocampal sclerosis (HS). The subiculum is an important area which c...

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Bibliographic Details
Main Authors: Aoyama, Beatriz Bertelli, Vieira, Andre Schwambach, Canto, Amanda Morato do, Berenguer, Alexandre Hilário, Carvalho, Benilton de Sá, Cendes, Iscia Lopes
Format: Online
Language:English
Published: Universidade Estadual de Campinas 2018
Subjects:
Epilepsy
Subiculum
Transcriptomic.
Online Access:https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/191
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Summary:Mesial temporal lobe epilepsy (MTLE) is the most frequent type of epilepsy in adults and it is usually refractory to clinical treatments. In most patients with MTLE a characteristic histopathological lesion is observed, including hippocampal sclerosis (HS). The subiculum is an important area which connects the hippocampus with the enthorrinal cortex. In this study aims to understand the molecular role of the subiculum in MTLE in the classical model of pilocarpine using RNA-seq (RNA sequencing)
ISSN:2596-1969

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