Effects of three different classes of antidepressants in the proteome of a human oligodendrocyte culture
Depression is a complex and multifactorial neuropsychiatric disorder that affects 4% of the world's population. The main hypothesis that underlies its pathophysiology is about neuronal dysfunctions, with a focus on monoamines dysregulation. However, recent studies have shown disturbances in oli...
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| Main Authors: | , , |
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas
2019
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| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/1957 |
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| Summary: | Depression is a complex and multifactorial neuropsychiatric disorder that affects 4% of the world's population. The main hypothesis that underlies its pathophysiology is about neuronal dysfunctions, with a focus on monoamines dysregulation. However, recent studies have shown disturbances in oligodendrocytes and myelination in the pathophysiology of disease. Treatment for depression is mainly based on the use of antidepressants that modulate the levels of monoamines and their receptors, but their effects on oligodendrocytes are still scarce. Thus, the aim of this study is to investigate the proteome of a human oligodendrocyte cell line (MO3.13), treated with three different classes of antidepressants, in order to unreveal pathways and biological processes that could be implicated or associated with the pathophysiology and treatment of this disorder. |
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| ISSN: | 2596-1969 |
