Determination of Tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by HPLC-UV detector
The method of determining Tadalafil in a mixture with a complex of vitamins and minerals by HPLC was verified to be linear, precise, selective and accurate with the use of WATERS Nova-Pack® C8 (3.9x150) mm; 4 ?m column. The mobile phase used was water:acetonitrile:trifluoroacetic acid (60:40:0.1) at...
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2048 |
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| author | Muniz, Ana Rosa, Paulo |
| author_facet | Muniz, Ana Rosa, Paulo |
| author_sort | Muniz, Ana |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | The method of determining Tadalafil in a mixture with a complex of vitamins and minerals by HPLC was verified to be linear, precise, selective and accurate with the use of WATERS Nova-Pack® C8 (3.9x150) mm; 4 ?m column. The mobile phase used was water:acetonitrile:trifluoroacetic acid (60:40:0.1) at the flow rate of 1 mL/min with UV detection at 285 nm at ambient temperature. Linearity was determined between 0.08 and 0.11 mg/mL with a correlation factor of 0.998. Standard deviations of performed tests of precision and accuracy were insignificant and components of the matrix did not interfere in the retention time of Tadalafil, the method is selective. |
| first_indexed | 2025-10-08T13:56:11Z |
| format | Online |
| id | ojs-article-2048 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:56:11Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-20482025-09-26T14:39:16Z Determination of Tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by HPLC-UV detector Muniz, Ana Rosa, Paulo Tadalafil Vitamins and minerals Combination therapy The method of determining Tadalafil in a mixture with a complex of vitamins and minerals by HPLC was verified to be linear, precise, selective and accurate with the use of WATERS Nova-Pack® C8 (3.9x150) mm; 4 ?m column. The mobile phase used was water:acetonitrile:trifluoroacetic acid (60:40:0.1) at the flow rate of 1 mL/min with UV detection at 285 nm at ambient temperature. Linearity was determined between 0.08 and 0.11 mg/mL with a correlation factor of 0.998. Standard deviations of performed tests of precision and accuracy were insignificant and components of the matrix did not interfere in the retention time of Tadalafil, the method is selective. Universidade Estadual de Campinas 2019-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2048 10.20396/revpibic2720192048 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2048/2102 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Muniz, Ana Rosa, Paulo Tadalafil Vitamins and minerals Combination therapy Determination of Tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by HPLC-UV detector |
| title | Determination of Tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by HPLC-UV detector |
| title_full | Determination of Tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by HPLC-UV detector |
| title_fullStr | Determination of Tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by HPLC-UV detector |
| title_full_unstemmed | Determination of Tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by HPLC-UV detector |
| title_short | Determination of Tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by HPLC-UV detector |
| title_sort | determination of tadalafil in pharmaceutical preparation of combination therapy with complex of vitamins and minerals by hplc-uv detector |
| topic | Tadalafil Vitamins and minerals Combination therapy |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2048 |
| work_keys_str_mv | AT munizana determinationoftadalafilinpharmaceuticalpreparationofcombinationtherapywithcomplexofvitaminsandmineralsbyhplcuvdetector AT rosapaulo determinationoftadalafilinpharmaceuticalpreparationofcombinationtherapywithcomplexofvitaminsandmineralsbyhplcuvdetector |
