The Heck reaction applied to the synthesis of chlorambucil
The Heck reaction plays an important role in organic synthesis because of the versatility of aryl halides and olefins that can be employed. Therefore, a synthetic route to chlorambucil through the Heck reaction was proposed. However, the oxidative addition of the proposed halide to the palladium cat...
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| Main Authors: | , |
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2201 |
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| _version_ | 1864359013229002752 |
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| author | Santana, Victor Buffon, Regina |
| author_facet | Santana, Victor Buffon, Regina |
| author_sort | Santana, Victor |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | The Heck reaction plays an important role in organic synthesis because of the versatility of aryl halides and olefins that can be employed. Therefore, a synthetic route to chlorambucil through the Heck reaction was proposed. However, the oxidative addition of the proposed halide to the palladium catalyst was not sucessful. An alternative Heck-Matsuda approach showed better results for the synthesis of a carboxylic acid derivative of chlorambucil. |
| first_indexed | 2025-10-08T13:56:42Z |
| format | Online |
| id | ojs-article-2201 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:56:42Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-22012025-09-26T14:39:16Z The Heck reaction applied to the synthesis of chlorambucil Santana, Victor Buffon, Regina Chlorambucil Heck reaction Redox relay The Heck reaction plays an important role in organic synthesis because of the versatility of aryl halides and olefins that can be employed. Therefore, a synthetic route to chlorambucil through the Heck reaction was proposed. However, the oxidative addition of the proposed halide to the palladium catalyst was not sucessful. An alternative Heck-Matsuda approach showed better results for the synthesis of a carboxylic acid derivative of chlorambucil. Universidade Estadual de Campinas 2019-01-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2201 10.20396/revpibic2720192201 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2201/2256 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Santana, Victor Buffon, Regina Chlorambucil Heck reaction Redox relay The Heck reaction applied to the synthesis of chlorambucil |
| title | The Heck reaction applied to the synthesis of chlorambucil |
| title_full | The Heck reaction applied to the synthesis of chlorambucil |
| title_fullStr | The Heck reaction applied to the synthesis of chlorambucil |
| title_full_unstemmed | The Heck reaction applied to the synthesis of chlorambucil |
| title_short | The Heck reaction applied to the synthesis of chlorambucil |
| title_sort | heck reaction applied to the synthesis of chlorambucil |
| topic | Chlorambucil Heck reaction Redox relay |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2201 |
| work_keys_str_mv | AT santanavictor theheckreactionappliedtothesynthesisofchlorambucil AT buffonregina theheckreactionappliedtothesynthesisofchlorambucil AT santanavictor heckreactionappliedtothesynthesisofchlorambucil AT buffonregina heckreactionappliedtothesynthesisofchlorambucil |
