The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet
Studies has shown that the consumption of a high-fat diet induces hypothalamic and systemic inflammation. It is also known that nicotinic acetylcholine receptors (nAChRs) are involved in cholinergic anti-inflammatory response, in which the ?7-subunit is the most expressive subtype doing this control...
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| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | Portuguese |
| Published: |
Universidade Estadual de Campinas
2019
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| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2302 |
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| Summary: | Studies has shown that the consumption of a high-fat diet induces hypothalamic and systemic inflammation. It is also known that nicotinic acetylcholine receptors (nAChRs) are involved in cholinergic anti-inflammatory response, in which the ?7-subunit is the most expressive subtype doing this control in immune cells. This study investigated the effects of a short-term high-fat diet on modulating the anti-inflammatory pathway mediated by ?7 receptor. 8-weeks-old Swiss mice consumed either short-term (3 days) high-fat diet (HFD-60% of fatty acids) or standard-chow. Both groups were submitted to either a CLP surgery, to induce polymicrobial sepsis, or an abdominal incision for exposure of the cecum, serving as the control group. We concluded that the consumption of a high-fat diet even for a short period is already capable of increasing hypothalamic anti-inflammatory markers and inhibiting the anti-inflammatory path-way. |
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| ISSN: | 2596-1969 |
