The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet
Studies has shown that the consumption of a high-fat diet induces hypothalamic and systemic inflammation. It is also known that nicotinic acetylcholine receptors (nAChRs) are involved in cholinergic anti-inflammatory response, in which the ?7-subunit is the most expressive subtype doing this control...
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| Autores principales: | , , , , , , , , |
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| Formato: | Online |
| Lenguaje: | portugués |
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Universidade Estadual de Campinas
2019
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| Acceso en línea: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2302 |
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| _version_ | 1864359039474860032 |
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| author | Santucci, Leticia Torsoni, Marcio Souza, Anelise de Souza, Camilla Amaral, Camila do Costa, Suleyma Lanza, Pamela Martins, Isis Contieri, Leticia |
| author_facet | Santucci, Leticia Torsoni, Marcio Souza, Anelise de Souza, Camilla Amaral, Camila do Costa, Suleyma Lanza, Pamela Martins, Isis Contieri, Leticia |
| author_sort | Santucci, Leticia |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | Studies has shown that the consumption of a high-fat diet induces hypothalamic and systemic inflammation. It is also known that nicotinic acetylcholine receptors (nAChRs) are involved in cholinergic anti-inflammatory response, in which the ?7-subunit is the most expressive subtype doing this control in immune cells. This study investigated the effects of a short-term high-fat diet on modulating the anti-inflammatory pathway mediated by ?7 receptor. 8-weeks-old Swiss mice consumed either short-term (3 days) high-fat diet (HFD-60% of fatty acids) or standard-chow. Both groups were submitted to either a CLP surgery, to induce polymicrobial sepsis, or an abdominal incision for exposure of the cecum, serving as the control group. We concluded that the consumption of a high-fat diet even for a short period is already capable of increasing hypothalamic anti-inflammatory markers and inhibiting the anti-inflammatory path-way. |
| first_indexed | 2025-10-08T13:57:01Z |
| format | Online |
| id | ojs-article-2302 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:57:01Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-23022025-09-26T14:39:16Z The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet Santucci, Leticia Torsoni, Marcio Souza, Anelise de Souza, Camilla Amaral, Camila do Costa, Suleyma Lanza, Pamela Martins, Isis Contieri, Leticia Cholinergic anti-inflammatory reflex Cecal ligation puncture High-fat diet Studies has shown that the consumption of a high-fat diet induces hypothalamic and systemic inflammation. It is also known that nicotinic acetylcholine receptors (nAChRs) are involved in cholinergic anti-inflammatory response, in which the ?7-subunit is the most expressive subtype doing this control in immune cells. This study investigated the effects of a short-term high-fat diet on modulating the anti-inflammatory pathway mediated by ?7 receptor. 8-weeks-old Swiss mice consumed either short-term (3 days) high-fat diet (HFD-60% of fatty acids) or standard-chow. Both groups were submitted to either a CLP surgery, to induce polymicrobial sepsis, or an abdominal incision for exposure of the cecum, serving as the control group. We concluded that the consumption of a high-fat diet even for a short period is already capable of increasing hypothalamic anti-inflammatory markers and inhibiting the anti-inflammatory path-way. Universidade Estadual de Campinas 2019-01-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2302 10.20396/revpibic2720192302 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2302/2351 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Santucci, Leticia Torsoni, Marcio Souza, Anelise de Souza, Camilla Amaral, Camila do Costa, Suleyma Lanza, Pamela Martins, Isis Contieri, Leticia Cholinergic anti-inflammatory reflex Cecal ligation puncture High-fat diet The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet |
| title | The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet |
| title_full | The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet |
| title_fullStr | The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet |
| title_full_unstemmed | The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet |
| title_short | The hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (CLP) procedure after the consumption of a short-term high-fat diet |
| title_sort | hypothalamic inflammation on a mice model of sepsis induced by cecal ligation puncture (clp) procedure after the consumption of a short-term high-fat diet |
| topic | Cholinergic anti-inflammatory reflex Cecal ligation puncture High-fat diet |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2302 |
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