New therapeutic approaches for non-muscle invasive bladder cancer (NMIBC): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (PRP)
This study characterized the effects of the immunotherapy using the nanostructured complex OncoTherad, either associated or not to Platelet-Rich Plasm (PRP) on the non-muscle invasive bladder cancer (NMIBC) chemically induced in mice. The treatment with OncoTherad inhibited the cancer’s progression...
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| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2499 |
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| author | Camargo, Gabriela Favaro, Wagner Sasaki, Bianca Reis, Ianny Dias, Queila Durán, Nélson |
| author_facet | Camargo, Gabriela Favaro, Wagner Sasaki, Bianca Reis, Ianny Dias, Queila Durán, Nélson |
| author_sort | Camargo, Gabriela |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | This study characterized the effects of the immunotherapy using the nanostructured complex OncoTherad, either associated or not to Platelet-Rich Plasm (PRP) on the non-muscle invasive bladder cancer (NMIBC) chemically induced in mice. The treatment with OncoTherad inhibited the cancer’s progression and promoted tumoral regression in 85.7% and the OncoTherad associated with PRP in 71.4% of the animals. Thus, the immunotherapy using OncoTherad associated to PRP raises as a new therapeutic strategy for NMIBC, which allows the treatment’s personalization and the reduction of the immunogenicity to patients who either show recurrence, are resistant to the therapy using Bacillus Calmette-Guérin (BCG) or are ineligible to the radical cystectomy.The immune system modulation and the relation of OncoTherad with the activated platelets demand continuity of studies to detail the mechanisms of this association. |
| first_indexed | 2025-10-08T13:57:39Z |
| format | Online |
| id | ojs-article-2499 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:57:39Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-24992025-09-26T14:39:16Z New therapeutic approaches for non-muscle invasive bladder cancer (NMIBC): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (PRP) Camargo, Gabriela Favaro, Wagner Sasaki, Bianca Reis, Ianny Dias, Queila Durán, Nélson Bladder cancer OncoTherad Platelet rich plasma This study characterized the effects of the immunotherapy using the nanostructured complex OncoTherad, either associated or not to Platelet-Rich Plasm (PRP) on the non-muscle invasive bladder cancer (NMIBC) chemically induced in mice. The treatment with OncoTherad inhibited the cancer’s progression and promoted tumoral regression in 85.7% and the OncoTherad associated with PRP in 71.4% of the animals. Thus, the immunotherapy using OncoTherad associated to PRP raises as a new therapeutic strategy for NMIBC, which allows the treatment’s personalization and the reduction of the immunogenicity to patients who either show recurrence, are resistant to the therapy using Bacillus Calmette-Guérin (BCG) or are ineligible to the radical cystectomy.The immune system modulation and the relation of OncoTherad with the activated platelets demand continuity of studies to detail the mechanisms of this association. Universidade Estadual de Campinas 2019-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2499 10.20396/revpibic2720192499 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2499/2531 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Camargo, Gabriela Favaro, Wagner Sasaki, Bianca Reis, Ianny Dias, Queila Durán, Nélson Bladder cancer OncoTherad Platelet rich plasma New therapeutic approaches for non-muscle invasive bladder cancer (NMIBC): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (PRP) |
| title | New therapeutic approaches for non-muscle invasive bladder cancer (NMIBC): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (PRP) |
| title_full | New therapeutic approaches for non-muscle invasive bladder cancer (NMIBC): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (PRP) |
| title_fullStr | New therapeutic approaches for non-muscle invasive bladder cancer (NMIBC): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (PRP) |
| title_full_unstemmed | New therapeutic approaches for non-muscle invasive bladder cancer (NMIBC): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (PRP) |
| title_short | New therapeutic approaches for non-muscle invasive bladder cancer (NMIBC): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (PRP) |
| title_sort | new therapeutic approaches for non-muscle invasive bladder cancer (nmibc): intravesical use of oncotherad biological response modifier and its association with platelet-rich plasma (prp) |
| topic | Bladder cancer OncoTherad Platelet rich plasma |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2499 |
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