The role of polyamines in activation of macrophages
The polyamines are small molecules cationic that occurs naturally in eukaryotic cells. Part of polyamines are the putrescine, spermidine and spermine with roles in cell development, proliferation and cell differentiation. The macrophages are extremely versatile and plastic cell from innate immunity,...
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2602 |
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| author | Souza, Douglas de Vieira, Pedro Davanzo, Gustavo |
| author_facet | Souza, Douglas de Vieira, Pedro Davanzo, Gustavo |
| author_sort | Souza, Douglas de |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | The polyamines are small molecules cationic that occurs naturally in eukaryotic cells. Part of polyamines are the putrescine, spermidine and spermine with roles in cell development, proliferation and cell differentiation. The macrophages are extremely versatile and plastic cell from innate immunity, which are responding the environment influences. Macrophages can be classified as pro-inflammatory (M1) and anti-inflammatory (M2). The first profile yeild cytokines as TNF-? and IL-1?, with properties anti-tumoral response, anti-microbial and the glycolytic metabolism. The second profile yield cytokines as IL-10 (M2), with proprieties wound healing and the oxidative phosphorilation metabolism. Macrophages treated with polyamines could change from an pro-inflammatory to anti-inflammatory profile or reduce the pro-inflammatory profile. Putrescine has more positive effective in reduction TNF-? and spermine, despite higher doses, in reducing IL-6. More experiments are required to fully undertand the mechanism of polyamines. |
| first_indexed | 2025-10-08T13:57:57Z |
| format | Online |
| id | ojs-article-2602 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:57:57Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-26022025-09-26T14:39:16Z The role of polyamines in activation of macrophages Souza, Douglas de Vieira, Pedro Davanzo, Gustavo Polyamines Macrophages Polarization The polyamines are small molecules cationic that occurs naturally in eukaryotic cells. Part of polyamines are the putrescine, spermidine and spermine with roles in cell development, proliferation and cell differentiation. The macrophages are extremely versatile and plastic cell from innate immunity, which are responding the environment influences. Macrophages can be classified as pro-inflammatory (M1) and anti-inflammatory (M2). The first profile yeild cytokines as TNF-? and IL-1?, with properties anti-tumoral response, anti-microbial and the glycolytic metabolism. The second profile yield cytokines as IL-10 (M2), with proprieties wound healing and the oxidative phosphorilation metabolism. Macrophages treated with polyamines could change from an pro-inflammatory to anti-inflammatory profile or reduce the pro-inflammatory profile. Putrescine has more positive effective in reduction TNF-? and spermine, despite higher doses, in reducing IL-6. More experiments are required to fully undertand the mechanism of polyamines. Universidade Estadual de Campinas 2019-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2602 10.20396/revpibic2720192602 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2602/2616 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Souza, Douglas de Vieira, Pedro Davanzo, Gustavo Polyamines Macrophages Polarization The role of polyamines in activation of macrophages |
| title | The role of polyamines in activation of macrophages |
| title_full | The role of polyamines in activation of macrophages |
| title_fullStr | The role of polyamines in activation of macrophages |
| title_full_unstemmed | The role of polyamines in activation of macrophages |
| title_short | The role of polyamines in activation of macrophages |
| title_sort | role of polyamines in activation of macrophages |
| topic | Polyamines Macrophages Polarization |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2602 |
| work_keys_str_mv | AT souzadouglasde theroleofpolyaminesinactivationofmacrophages AT vieirapedro theroleofpolyaminesinactivationofmacrophages AT davanzogustavo theroleofpolyaminesinactivationofmacrophages AT souzadouglasde roleofpolyaminesinactivationofmacrophages AT vieirapedro roleofpolyaminesinactivationofmacrophages AT davanzogustavo roleofpolyaminesinactivationofmacrophages |
