Human colorectal cancer cells become more responsive to Vemurafenib after sensitization with 3-Bromopyruvate
Colorectal cancer (CRC) is the second most common malignant neoplasm in women and the third most prevalent in men worldwide. In Brazil, about 36,000 new cases of CRC are estimated among men and women for 2018-2019. With advances in treatment, early CRC is being “reclassified” from a deadly disease t...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | Portuguese |
| Published: |
Universidade Estadual de Campinas
2019
|
| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2607 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864359116123668480 |
|---|---|
| author | Araujo, Laura de Halder, Carmen |
| author_facet | Araujo, Laura de Halder, Carmen |
| author_sort | Araujo, Laura de |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | Colorectal cancer (CRC) is the second most common malignant neoplasm in women and the third most prevalent in men worldwide. In Brazil, about 36,000 new cases of CRC are estimated among men and women for 2018-2019. With advances in treatment, early CRC is being “reclassified” from a deadly disease to an illness that has great chance of cure. However, so far, the survivors who have completed treatment and are cancer-free, frequently suffer from late/long-term side effects, and some patients with metastasis have poor response to the therapies. In this context, the discovery of new therapeutic strategies is urgently needed. In this project we aimed to validate the hypothesis that 3-Bromopyruvate (3-BP), an alkylating agent, would be able to sensitize the human CRC cell lines to treatment with Vemurafenib, a BRAF inhibitor. Therefore, human CRC cell lines (HT-29 and HCT-116) were challenged with 3-BP followed by the treatment with Vemurafenib. Both cell lines were more responsive to Vemurafenib after sensitization with 3-BP (IC50 values were 7- and 1.4-fold lower than with Vemurafenib alone, for HT-29 and HCT-116 cells, respectively). The findings presented here, highlight the potential of 3-BP in increasing the response of metastatic cancer cells to Vemurafenib. |
| first_indexed | 2025-10-08T13:57:58Z |
| format | Online |
| id | ojs-article-2607 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:57:58Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-26072025-09-26T14:39:16Z Human colorectal cancer cells become more responsive to Vemurafenib after sensitization with 3-Bromopyruvate Araujo, Laura de Halder, Carmen Colorectal cancer 3-Bromopyruvate Vemurafenib Colorectal cancer (CRC) is the second most common malignant neoplasm in women and the third most prevalent in men worldwide. In Brazil, about 36,000 new cases of CRC are estimated among men and women for 2018-2019. With advances in treatment, early CRC is being “reclassified” from a deadly disease to an illness that has great chance of cure. However, so far, the survivors who have completed treatment and are cancer-free, frequently suffer from late/long-term side effects, and some patients with metastasis have poor response to the therapies. In this context, the discovery of new therapeutic strategies is urgently needed. In this project we aimed to validate the hypothesis that 3-Bromopyruvate (3-BP), an alkylating agent, would be able to sensitize the human CRC cell lines to treatment with Vemurafenib, a BRAF inhibitor. Therefore, human CRC cell lines (HT-29 and HCT-116) were challenged with 3-BP followed by the treatment with Vemurafenib. Both cell lines were more responsive to Vemurafenib after sensitization with 3-BP (IC50 values were 7- and 1.4-fold lower than with Vemurafenib alone, for HT-29 and HCT-116 cells, respectively). The findings presented here, highlight the potential of 3-BP in increasing the response of metastatic cancer cells to Vemurafenib. Universidade Estadual de Campinas 2019-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2607 10.20396/revpibic2720192607 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2607/2620 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Araujo, Laura de Halder, Carmen Colorectal cancer 3-Bromopyruvate Vemurafenib Human colorectal cancer cells become more responsive to Vemurafenib after sensitization with 3-Bromopyruvate |
| title | Human colorectal cancer cells become more responsive to Vemurafenib after sensitization with 3-Bromopyruvate |
| title_full | Human colorectal cancer cells become more responsive to Vemurafenib after sensitization with 3-Bromopyruvate |
| title_fullStr | Human colorectal cancer cells become more responsive to Vemurafenib after sensitization with 3-Bromopyruvate |
| title_full_unstemmed | Human colorectal cancer cells become more responsive to Vemurafenib after sensitization with 3-Bromopyruvate |
| title_short | Human colorectal cancer cells become more responsive to Vemurafenib after sensitization with 3-Bromopyruvate |
| title_sort | human colorectal cancer cells become more responsive to vemurafenib after sensitization with 3-bromopyruvate |
| topic | Colorectal cancer 3-Bromopyruvate Vemurafenib |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2607 |
| work_keys_str_mv | AT araujolaurade humancolorectalcancercellsbecomemoreresponsivetovemurafenibaftersensitizationwith3bromopyruvate AT haldercarmen humancolorectalcancercellsbecomemoreresponsivetovemurafenibaftersensitizationwith3bromopyruvate |
