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Evaluation of the H3K9ac immunoexpression in lip carcinogenesis

Actinic cheilitis (AC) is a potentially malignant lesion caused by long period sun exposure. Mainly affects the lower lip and can develop into a lip squamous cell carcinoma (LSCC). Acetylation of lysine 9 in histone 3 (H3K9ac) is an epigenetic mechanism that regulates gene expression by chromatin de...

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Bibliographic Details
Main Authors: Estevan, Mariana, Vargas, Pablo, Amaral-Silva, Gleyson, Wagner, Vivian, Mariz, Bruno, Santos-Silva, Alan, Lopes, Marcio, Almeida, Oslei
Format: Online
Language:Portuguese
Published: Universidade Estadual de Campinas 2019
Subjects:
Histones
Epigenetic process
Lip neoplasm
Online Access:https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2623
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Summary:Actinic cheilitis (AC) is a potentially malignant lesion caused by long period sun exposure. Mainly affects the lower lip and can develop into a lip squamous cell carcinoma (LSCC). Acetylation of lysine 9 in histone 3 (H3K9ac) is an epigenetic mechanism that regulates gene expression by chromatin decondensation. H3K9ac was more intense in LSCC (n=40) than AC (n=42) and LNM(n=47). No differences were observed between LSCC and AC (WHO – Severe dysplasia; Binary System – High risk). Our results suggest that H3K9ac could be a promising marker to indicate AC’s malignization.
ISSN:2596-1969

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