Metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance
Mesial temporal lobe epilepsy (MTLE) stands out among the different types of epilepsy due to its prevalence and the high rate of resistance to the treatment with antiepileptic drugs (AEDs). Because of the challenge to predict which patients will respond to drug treatments, alternative therapies to s...
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| Formato: | Online |
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Universidade Estadual de Campinas
2019
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| Acceso en línea: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2701 |
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| _version_ | 1864359186108776448 |
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| author | Godoi, Alexandre de Cendes, Iscia Canto, Amanda do Donatti, Amanda Rosa, Douglas Martin, Mariana Yasuda, Clarissa Quintero, Melissa Cendes, Fernando Tasic, Ljubica Alvim, Mariana |
| author_facet | Godoi, Alexandre de Cendes, Iscia Canto, Amanda do Donatti, Amanda Rosa, Douglas Martin, Mariana Yasuda, Clarissa Quintero, Melissa Cendes, Fernando Tasic, Ljubica Alvim, Mariana |
| author_sort | Godoi, Alexandre de |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | Mesial temporal lobe epilepsy (MTLE) stands out among the different types of epilepsy due to its prevalence and the high rate of resistance to the treatment with antiepileptic drugs (AEDs). Because of the challenge to predict which patients will respond to drug treatments, alternative therapies to seizures, such as epilepsy surgery, may take many years to be indicated. Thereby, the search for new biomarkers, capable of predicting which pateitns witll be AED resistance is necessary. The metabolomic approach has many advantages over other molecular techniques, such as greater proximity of the metabolites to the phenotype and high sensitivity and specificity in the detection of these analytes. Therefore, the main objective of the present sutidy is to use metabolomics to find biomarkers of AED resistance in patients with MTLE. |
| first_indexed | 2025-10-08T13:58:16Z |
| format | Online |
| id | ojs-article-2701 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:58:16Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-27012025-09-26T14:39:16Z Metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance Godoi, Alexandre de Cendes, Iscia Canto, Amanda do Donatti, Amanda Rosa, Douglas Martin, Mariana Yasuda, Clarissa Quintero, Melissa Cendes, Fernando Tasic, Ljubica Alvim, Mariana Mesial temporal lobe epilepsy Metabolomics Proton nuclear magnetic resonance Mesial temporal lobe epilepsy (MTLE) stands out among the different types of epilepsy due to its prevalence and the high rate of resistance to the treatment with antiepileptic drugs (AEDs). Because of the challenge to predict which patients will respond to drug treatments, alternative therapies to seizures, such as epilepsy surgery, may take many years to be indicated. Thereby, the search for new biomarkers, capable of predicting which pateitns witll be AED resistance is necessary. The metabolomic approach has many advantages over other molecular techniques, such as greater proximity of the metabolites to the phenotype and high sensitivity and specificity in the detection of these analytes. Therefore, the main objective of the present sutidy is to use metabolomics to find biomarkers of AED resistance in patients with MTLE. Universidade Estadual de Campinas 2019-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2701 10.20396/revpibic2720192701 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2701/2711 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Godoi, Alexandre de Cendes, Iscia Canto, Amanda do Donatti, Amanda Rosa, Douglas Martin, Mariana Yasuda, Clarissa Quintero, Melissa Cendes, Fernando Tasic, Ljubica Alvim, Mariana Mesial temporal lobe epilepsy Metabolomics Proton nuclear magnetic resonance Metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance |
| title | Metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance |
| title_full | Metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance |
| title_fullStr | Metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance |
| title_full_unstemmed | Metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance |
| title_short | Metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance |
| title_sort | metabolomic analysis of blood plasma from patients with mesial temporal lobe epilepsy: a search for biomarkers of drug resistance |
| topic | Mesial temporal lobe epilepsy Metabolomics Proton nuclear magnetic resonance |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2701 |
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