Metabolomic profiles of patients with ischemic stroke: searching for biomarkers
Ischemic stroke (IS) is one of the most common causes of mortality worldwide and represents 80% of all stroke cases. Previous studies have shown that some metabolites can be markers of oxidative injury to vascular endothelial cells and neuromodulation after brain ischemia. Biomarkers are small molec...
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| Main Authors: | , , , , , , , , , |
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2835 |
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| author | Rosa, Douglas da Cendes, Iscia Donatti, Amanda Oliveira, Fabiana Godoi, Alexandre Canto, Amanda Sousa, Alessandro Avelar, Wagner Quintero, Melissa Tasic, Ljubica |
| author_facet | Rosa, Douglas da Cendes, Iscia Donatti, Amanda Oliveira, Fabiana Godoi, Alexandre Canto, Amanda Sousa, Alessandro Avelar, Wagner Quintero, Melissa Tasic, Ljubica |
| author_sort | Rosa, Douglas da |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | Ischemic stroke (IS) is one of the most common causes of mortality worldwide and represents 80% of all stroke cases. Previous studies have shown that some metabolites can be markers of oxidative injury to vascular endothelial cells and neuromodulation after brain ischemia. Biomarkers are small molecules that are dysregulated during diseases and that can be used to improve diagnosis and to determine prognosis, including responses to treatment. This study aims to identify if there are specific metabolites in the plasma of patients with IS in the acute and chronic stages. Currently, we have evaluated plasma samples of 21 individuals, using proton Nuclear Magnetic Resonance (1H NMR). The samples were divided into 4 groups: 6 samples from patients in the acute phase of IS (less than 24 h after the event), 6 samples from patients in the chronic phase of IS (more than 3 months after the acure event), 5 samples from healthy and agematched individuals and 4 samples from asymptomatic patients with severe internal carotid artery stenosis. Samples were evaluated using 1 H NMR spectra, recorded under the same conditions in a 600 MHz spectrometer. |
| first_indexed | 2025-10-08T13:58:42Z |
| format | Online |
| id | ojs-article-2835 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:58:42Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-28352025-09-26T14:39:16Z Metabolomic profiles of patients with ischemic stroke: searching for biomarkers Rosa, Douglas da Cendes, Iscia Donatti, Amanda Oliveira, Fabiana Godoi, Alexandre Canto, Amanda Sousa, Alessandro Avelar, Wagner Quintero, Melissa Tasic, Ljubica Stroke Metabolomics 1H NMR Ischemic stroke (IS) is one of the most common causes of mortality worldwide and represents 80% of all stroke cases. Previous studies have shown that some metabolites can be markers of oxidative injury to vascular endothelial cells and neuromodulation after brain ischemia. Biomarkers are small molecules that are dysregulated during diseases and that can be used to improve diagnosis and to determine prognosis, including responses to treatment. This study aims to identify if there are specific metabolites in the plasma of patients with IS in the acute and chronic stages. Currently, we have evaluated plasma samples of 21 individuals, using proton Nuclear Magnetic Resonance (1H NMR). The samples were divided into 4 groups: 6 samples from patients in the acute phase of IS (less than 24 h after the event), 6 samples from patients in the chronic phase of IS (more than 3 months after the acure event), 5 samples from healthy and agematched individuals and 4 samples from asymptomatic patients with severe internal carotid artery stenosis. Samples were evaluated using 1 H NMR spectra, recorded under the same conditions in a 600 MHz spectrometer. Universidade Estadual de Campinas 2019-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2835 10.20396/revpibic2720192835 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2835/2835 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Rosa, Douglas da Cendes, Iscia Donatti, Amanda Oliveira, Fabiana Godoi, Alexandre Canto, Amanda Sousa, Alessandro Avelar, Wagner Quintero, Melissa Tasic, Ljubica Stroke Metabolomics 1H NMR Metabolomic profiles of patients with ischemic stroke: searching for biomarkers |
| title | Metabolomic profiles of patients with ischemic stroke: searching for biomarkers |
| title_full | Metabolomic profiles of patients with ischemic stroke: searching for biomarkers |
| title_fullStr | Metabolomic profiles of patients with ischemic stroke: searching for biomarkers |
| title_full_unstemmed | Metabolomic profiles of patients with ischemic stroke: searching for biomarkers |
| title_short | Metabolomic profiles of patients with ischemic stroke: searching for biomarkers |
| title_sort | metabolomic profiles of patients with ischemic stroke: searching for biomarkers |
| topic | Stroke Metabolomics 1H NMR |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2835 |
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