Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics
Lipids can be used to create vectors for delivery of drugs, as well as genetic material. This work focused on the production of complexes between liposomes (with and without polyethylene glycol, PEG) and plasmidial DNA and small interfering RNA. Two mechanisms of production (complexation) were explo...
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| Main Authors: | , , |
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| Format: | Online |
| Language: | Portuguese |
| Published: |
Universidade Estadual de Campinas
2019
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| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/3000 |
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| Summary: | Lipids can be used to create vectors for delivery of drugs, as well as genetic material. This work focused on the production of complexes between liposomes (with and without polyethylene glycol, PEG) and plasmidial DNA and small interfering RNA. Two mechanisms of production (complexation) were explored, one forms lipoplexes and lipid nanoparticles. Both structures formed were very different, resulting in distinct physical-chemical properties. |
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| ISSN: | 2596-1969 |
