Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics
Lipids can be used to create vectors for delivery of drugs, as well as genetic material. This work focused on the production of complexes between liposomes (with and without polyethylene glycol, PEG) and plasmidial DNA and small interfering RNA. Two mechanisms of production (complexation) were explo...
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| Main Authors: | , , |
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/3000 |
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| _version_ | 1864359341995327488 |
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| author | Montebugnoli, Leonardo Torre, Lucimara de La Es, Ismail |
| author_facet | Montebugnoli, Leonardo Torre, Lucimara de La Es, Ismail |
| author_sort | Montebugnoli, Leonardo |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | Lipids can be used to create vectors for delivery of drugs, as well as genetic material. This work focused on the production of complexes between liposomes (with and without polyethylene glycol, PEG) and plasmidial DNA and small interfering RNA. Two mechanisms of production (complexation) were explored, one forms lipoplexes and lipid nanoparticles. Both structures formed were very different, resulting in distinct physical-chemical properties. |
| first_indexed | 2025-10-08T13:59:16Z |
| format | Online |
| id | ojs-article-3000 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:59:16Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-30002025-09-26T14:39:16Z Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics Montebugnoli, Leonardo Torre, Lucimara de La Es, Ismail Microfluidic Complexation Gene therapy Lipids can be used to create vectors for delivery of drugs, as well as genetic material. This work focused on the production of complexes between liposomes (with and without polyethylene glycol, PEG) and plasmidial DNA and small interfering RNA. Two mechanisms of production (complexation) were explored, one forms lipoplexes and lipid nanoparticles. Both structures formed were very different, resulting in distinct physical-chemical properties. Universidade Estadual de Campinas 2019-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/3000 10.20396/revpibic2720193000 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/3000/2993 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Montebugnoli, Leonardo Torre, Lucimara de La Es, Ismail Microfluidic Complexation Gene therapy Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics |
| title | Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics |
| title_full | Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics |
| title_fullStr | Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics |
| title_full_unstemmed | Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics |
| title_short | Evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics |
| title_sort | evaluation of the electrostatic association between cationic and stealth liposomes with nucleic acids in microfluidics |
| topic | Microfluidic Complexation Gene therapy |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/3000 |
| work_keys_str_mv | AT montebugnolileonardo evaluationoftheelectrostaticassociationbetweencationicandstealthliposomeswithnucleicacidsinmicrofluidics AT torrelucimaradela evaluationoftheelectrostaticassociationbetweencationicandstealthliposomeswithnucleicacidsinmicrofluidics AT esismail evaluationoftheelectrostaticassociationbetweencationicandstealthliposomeswithnucleicacidsinmicrofluidics |
