Air pollution participates in genesis of obesity through the activation of hypothalamic
Air pollution is involved in several processes harmful to health. PM2,5 is the most associated with the induction of chronic inflammation. Hypothalamus regulates the energy homeostasis thought metabolic, neural and hormonal signals. Leptin signaling participates in this process, and hypothalamic inf...
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| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2018
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/311 |
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| author | Campolim, Clara Machado Prada, Patricia de Oliveira Ferreira, Clilton Krauss de Oliveira Boico, Vitor Ferreira Zordão, Olivia Pizetta Costa, Soraia K. Veras, Mariana Matera Saldiva, Paulo Hilário Nascimento |
| author_facet | Campolim, Clara Machado Prada, Patricia de Oliveira Ferreira, Clilton Krauss de Oliveira Boico, Vitor Ferreira Zordão, Olivia Pizetta Costa, Soraia K. Veras, Mariana Matera Saldiva, Paulo Hilário Nascimento |
| author_sort | Campolim, Clara Machado |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | Air pollution is involved in several processes harmful to health. PM2,5 is the most associated with the induction of chronic inflammation. Hypothalamus regulates the energy homeostasis thought metabolic, neural and hormonal signals. Leptin signaling participates in this process, and hypothalamic inflammation may induce leptin resistance. TLR4 is an innate immune receptor capable of triggering subclinical inflammation, and one of its agonists is LPS, which is known be present in the PM2.5 composition. Polluted C57 mice had increased adiposity due to hyperphagia and lower energy expenditure, caused by leptin resistance. The TLR4 gene expression was elevated in the hypothalamus of polluted C57. The TLR4 deletion protected the animal from obesity, glucose intolerance, and leptin resistance when exposed to PM2.5. Together, these results suggest that air pollution induces hypothalamic leptin resistance by the activation of inflammatory pathways, probably involving TLR4. |
| first_indexed | 2025-10-08T13:50:23Z |
| format | Online |
| id | ojs-article-311 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:50:23Z |
| publishDate | 2018 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-3112025-09-26T14:32:30Z Air pollution participates in genesis of obesity through the activation of hypothalamic Campolim, Clara Machado Prada, Patricia de Oliveira Ferreira, Clilton Krauss de Oliveira Boico, Vitor Ferreira Zordão, Olivia Pizetta Costa, Soraia K. Veras, Mariana Matera Saldiva, Paulo Hilário Nascimento Obesity Air pollution Hypothalamic leptin action. Air pollution is involved in several processes harmful to health. PM2,5 is the most associated with the induction of chronic inflammation. Hypothalamus regulates the energy homeostasis thought metabolic, neural and hormonal signals. Leptin signaling participates in this process, and hypothalamic inflammation may induce leptin resistance. TLR4 is an innate immune receptor capable of triggering subclinical inflammation, and one of its agonists is LPS, which is known be present in the PM2.5 composition. Polluted C57 mice had increased adiposity due to hyperphagia and lower energy expenditure, caused by leptin resistance. The TLR4 gene expression was elevated in the hypothalamus of polluted C57. The TLR4 deletion protected the animal from obesity, glucose intolerance, and leptin resistance when exposed to PM2.5. Together, these results suggest that air pollution induces hypothalamic leptin resistance by the activation of inflammatory pathways, probably involving TLR4. Universidade Estadual de Campinas 2018-12-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/311 10.20396/revpibic262018311 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/311/292 Copyright (c) 2018 Clara Machado Campolim, Patricia de Oliveira Prada http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Campolim, Clara Machado Prada, Patricia de Oliveira Ferreira, Clilton Krauss de Oliveira Boico, Vitor Ferreira Zordão, Olivia Pizetta Costa, Soraia K. Veras, Mariana Matera Saldiva, Paulo Hilário Nascimento Obesity Air pollution Hypothalamic leptin action. Air pollution participates in genesis of obesity through the activation of hypothalamic |
| title | Air pollution participates in genesis of obesity through the activation of hypothalamic |
| title_full | Air pollution participates in genesis of obesity through the activation of hypothalamic |
| title_fullStr | Air pollution participates in genesis of obesity through the activation of hypothalamic |
| title_full_unstemmed | Air pollution participates in genesis of obesity through the activation of hypothalamic |
| title_short | Air pollution participates in genesis of obesity through the activation of hypothalamic |
| title_sort | air pollution participates in genesis of obesity through the activation of hypothalamic |
| topic | Obesity Air pollution Hypothalamic leptin action. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/311 |
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