Alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity
The Alternanthera paronychioides has been studied by their notorious anti-glucotoxic activity, however the chemical characterization had not been done yet. With the use of HPLC-UV-DAD and UPLC-ESI-MS/MS the present work allowed to identify four heterosides possibly associated with the anti-glucotoxi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Universidade Estadual de Campinas
2019
|
| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/441 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864358411066408960 |
|---|---|
| author | Bosso, Fernando Henrique Salvador, Marcos José |
| author_facet | Bosso, Fernando Henrique Salvador, Marcos José |
| author_sort | Bosso, Fernando Henrique |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | The Alternanthera paronychioides has been studied by their notorious anti-glucotoxic activity, however the chemical characterization had not been done yet. With the use of HPLC-UV-DAD and UPLC-ESI-MS/MS the present work allowed to identify four heterosides possibly associated with the anti-glucotoxic activity; Vitexin and Isovitexin, associated with the alpha-glucosidase inhibition, Flavosativaside and Rutin, associated with the aldose-reductase inhibition. The identified substances were quantified and the extraction methodology was optimized. The study allowed to clarify some of the pharmacological bases involved in the therapeutic uses of the specie, until then empirical. |
| first_indexed | 2025-10-08T13:50:50Z |
| format | Online |
| id | ojs-article-441 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:50:50Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-4412025-09-26T14:32:30Z Alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity Bosso, Fernando Henrique Salvador, Marcos José Alternanthera paronychioides Flavonoids Anti-glucotoxic activity. The Alternanthera paronychioides has been studied by their notorious anti-glucotoxic activity, however the chemical characterization had not been done yet. With the use of HPLC-UV-DAD and UPLC-ESI-MS/MS the present work allowed to identify four heterosides possibly associated with the anti-glucotoxic activity; Vitexin and Isovitexin, associated with the alpha-glucosidase inhibition, Flavosativaside and Rutin, associated with the aldose-reductase inhibition. The identified substances were quantified and the extraction methodology was optimized. The study allowed to clarify some of the pharmacological bases involved in the therapeutic uses of the specie, until then empirical. Universidade Estadual de Campinas 2019-01-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/441 10.20396/revpibic262018441 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/441/457 Copyright (c) 2019 Fernando Henrique Bosso, Marcos José Salvador http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Bosso, Fernando Henrique Salvador, Marcos José Alternanthera paronychioides Flavonoids Anti-glucotoxic activity. Alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity |
| title | Alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity |
| title_full | Alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity |
| title_fullStr | Alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity |
| title_full_unstemmed | Alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity |
| title_short | Alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity |
| title_sort | alternanthera paronychioides and the molecular basis of the anti-glucotoxic activity |
| topic | Alternanthera paronychioides Flavonoids Anti-glucotoxic activity. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/441 |
| work_keys_str_mv | AT bossofernandohenrique alternantheraparonychioidesandthemolecularbasisoftheantiglucotoxicactivity AT salvadormarcosjose alternantheraparonychioidesandthemolecularbasisoftheantiglucotoxicactivity |
