Anti-adhesive and anti-biofilm activity of NC-E08. In vitro and in vivo study using Galleria mellonella infection model
Biofilms are organized microbial communities formed from an ecological succession. Biofilm formation functions as a mechanism of virulence and favors the development of diseases, including oral diseases such as dental caries and periodontal disease, in which the microorganisms Streptococcus mutans a...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/506 |
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| author | Bombarda, Gabriela Fernanda Sardi, Janaina de Cássia Orlandi Rosalen, Pedro L. Lazarini, Josy G. Paganini, Eder R. Regasini, Luis O. |
| author_facet | Bombarda, Gabriela Fernanda Sardi, Janaina de Cássia Orlandi Rosalen, Pedro L. Lazarini, Josy G. Paganini, Eder R. Regasini, Luis O. |
| author_sort | Bombarda, Gabriela Fernanda |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | Biofilms are organized microbial communities formed from an ecological succession. Biofilm formation functions as a mechanism of virulence and favors the development of diseases, including oral diseases such as dental caries and periodontal disease, in which the microorganisms Streptococcus mutans and Candida albicans are closely related. Previous studies have shown that interactions between S. mutans and C. albicans are associated with the pathogenesis of early childhood caries (ECC). Therefore, there is a great interest in finding new prototypes for antimicrobial drugs, mainly for the development of structural analogues of chalcones, which constitute one of the largest classes of natural products belonging to the flavonoid family and are considered strategic molecules for this purpose. |
| first_indexed | 2025-10-08T13:51:04Z |
| format | Online |
| id | ojs-article-506 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:51:04Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-5062025-09-26T14:32:30Z Anti-adhesive and anti-biofilm activity of NC-E08. In vitro and in vivo study using Galleria mellonella infection model Bombarda, Gabriela Fernanda Sardi, Janaina de Cássia Orlandi Rosalen, Pedro L. Lazarini, Josy G. Paganini, Eder R. Regasini, Luis O. Dual biofims Toxicity Nitro-chalcone. Biofilms are organized microbial communities formed from an ecological succession. Biofilm formation functions as a mechanism of virulence and favors the development of diseases, including oral diseases such as dental caries and periodontal disease, in which the microorganisms Streptococcus mutans and Candida albicans are closely related. Previous studies have shown that interactions between S. mutans and C. albicans are associated with the pathogenesis of early childhood caries (ECC). Therefore, there is a great interest in finding new prototypes for antimicrobial drugs, mainly for the development of structural analogues of chalcones, which constitute one of the largest classes of natural products belonging to the flavonoid family and are considered strategic molecules for this purpose. Universidade Estadual de Campinas 2019-01-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/506 10.20396/revpibic262018506 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/506/496 Copyright (c) 2019 Gabriela Fernanda Bombarda, Janaina de Cássia Orlandi Sardi http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Bombarda, Gabriela Fernanda Sardi, Janaina de Cássia Orlandi Rosalen, Pedro L. Lazarini, Josy G. Paganini, Eder R. Regasini, Luis O. Dual biofims Toxicity Nitro-chalcone. Anti-adhesive and anti-biofilm activity of NC-E08. In vitro and in vivo study using Galleria mellonella infection model |
| title | Anti-adhesive and anti-biofilm activity of NC-E08. In vitro and in vivo study using Galleria mellonella infection model |
| title_full | Anti-adhesive and anti-biofilm activity of NC-E08. In vitro and in vivo study using Galleria mellonella infection model |
| title_fullStr | Anti-adhesive and anti-biofilm activity of NC-E08. In vitro and in vivo study using Galleria mellonella infection model |
| title_full_unstemmed | Anti-adhesive and anti-biofilm activity of NC-E08. In vitro and in vivo study using Galleria mellonella infection model |
| title_short | Anti-adhesive and anti-biofilm activity of NC-E08. In vitro and in vivo study using Galleria mellonella infection model |
| title_sort | anti-adhesive and anti-biofilm activity of nc-e08. in vitro and in vivo study using galleria mellonella infection model |
| topic | Dual biofims Toxicity Nitro-chalcone. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/506 |
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