Bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability
Although bupivacaine (BVC) is one of the most widely used anesthetics worldwide, improving its therapeutic efficacy without increasing the clinical doses may open possibilities for new applications for this drug. In this study, we prepared innovative formulations: nanostructured lipid carriers (NLC)...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Universidade Estadual de Campinas
2019
|
| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/509 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864358431136153600 |
|---|---|
| author | Geronimo, Gabriela Paula, Eneida de Silva, Gustavo Henrique Rodrigues da Ribeiro, Lígia Nunes de Morais |
| author_facet | Geronimo, Gabriela Paula, Eneida de Silva, Gustavo Henrique Rodrigues da Ribeiro, Lígia Nunes de Morais |
| author_sort | Geronimo, Gabriela |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | Although bupivacaine (BVC) is one of the most widely used anesthetics worldwide, improving its therapeutic efficacy without increasing the clinical doses may open possibilities for new applications for this drug. In this study, we prepared innovative formulations: nanostructured lipid carriers (NLC) functionalized with beeswax, lavender or melaleuca oil in order to increase the anesthetic efficiency of BVC. For this, after preparation and characterization of the NLC by dynamic light scattering and determination of the encapsulation efficiency (% EE), stability was monitored during 12 months. The NLC showed appropriate physical-chemical features, with high %EE and stability. The developed formulations proved to be good candidates to increase the therapeutic efficacy of BVC so that further in vitro and in vivo tests are under course to evaluate their advantages, in comparison to the commercial BVC formulation. |
| first_indexed | 2025-10-08T13:51:05Z |
| format | Online |
| id | ojs-article-509 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:51:05Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-5092025-09-26T14:32:30Z Bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability Geronimo, Gabriela Paula, Eneida de Silva, Gustavo Henrique Rodrigues da Ribeiro, Lígia Nunes de Morais Bupivacaine Nanostructured lipid carriers Drug-delivery. Although bupivacaine (BVC) is one of the most widely used anesthetics worldwide, improving its therapeutic efficacy without increasing the clinical doses may open possibilities for new applications for this drug. In this study, we prepared innovative formulations: nanostructured lipid carriers (NLC) functionalized with beeswax, lavender or melaleuca oil in order to increase the anesthetic efficiency of BVC. For this, after preparation and characterization of the NLC by dynamic light scattering and determination of the encapsulation efficiency (% EE), stability was monitored during 12 months. The NLC showed appropriate physical-chemical features, with high %EE and stability. The developed formulations proved to be good candidates to increase the therapeutic efficacy of BVC so that further in vitro and in vivo tests are under course to evaluate their advantages, in comparison to the commercial BVC formulation. Universidade Estadual de Campinas 2019-01-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/509 10.20396/revpibic262018509 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/509/499 Copyright (c) 2019 Gabriela Geronimo, Eneida de Paula http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Geronimo, Gabriela Paula, Eneida de Silva, Gustavo Henrique Rodrigues da Ribeiro, Lígia Nunes de Morais Bupivacaine Nanostructured lipid carriers Drug-delivery. Bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability |
| title | Bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability |
| title_full | Bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability |
| title_fullStr | Bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability |
| title_full_unstemmed | Bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability |
| title_short | Bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability |
| title_sort | bupivacaine-loaded nanostructured lipid carriers prepared with beeswax, lavender or melaleuca oil: characterization and physico-chemical stability |
| topic | Bupivacaine Nanostructured lipid carriers Drug-delivery. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/509 |
| work_keys_str_mv | AT geronimogabriela bupivacaineloadednanostructuredlipidcarrierspreparedwithbeeswaxlavenderormelaleucaoilcharacterizationandphysicochemicalstability AT paulaeneidade bupivacaineloadednanostructuredlipidcarrierspreparedwithbeeswaxlavenderormelaleucaoilcharacterizationandphysicochemicalstability AT silvagustavohenriquerodriguesda bupivacaineloadednanostructuredlipidcarrierspreparedwithbeeswaxlavenderormelaleucaoilcharacterizationandphysicochemicalstability AT ribeiroligianunesdemorais bupivacaineloadednanostructuredlipidcarrierspreparedwithbeeswaxlavenderormelaleucaoilcharacterizationandphysicochemicalstability |
