Leucine-rich diet alters the (1) H-NMRI serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid
Cancer-cachexia is a multifactorial chronic disease associated with high inflammation and loss of muscular and adipose tissues and affects 30% of cancer patients. A maternal diet with leucine could alter the inflammatory state and regulate protein synthesis positively, modulating the effects of cach...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/516 |
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| author | Santos, Gabriela Sales dos Marcondes, Maria Cristina Cintra Gomes Manhe, Beatriz Schincariol Silva, Natália Miyaguti Angelo da Oliveira, Sarah Christine Pereira de |
| author_facet | Santos, Gabriela Sales dos Marcondes, Maria Cristina Cintra Gomes Manhe, Beatriz Schincariol Silva, Natália Miyaguti Angelo da Oliveira, Sarah Christine Pereira de |
| author_sort | Santos, Gabriela Sales dos |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | Cancer-cachexia is a multifactorial chronic disease associated with high inflammation and loss of muscular and adipose tissues and affects 30% of cancer patients. A maternal diet with leucine could alter the inflammatory state and regulate protein synthesis positively, modulating the effects of cachexia. Metabolomic analyses are an important technique to value the effects of cachexia because of the identification of altered metabolites in serum samples and consequently evaluate the impacted metabolic pathways in these patients. Thus, we analysed the regulatory effects of maternal nutritional supplementation with leucine over the serum metabolic profile (using the 1H-NMR analysis) of the adult offspring rats bearing the Walker 256 tumour.The cachexia leads to a characteristic metabolic profile related to an increase in the glycolytic pathway, which is likely modulated by maternal leucine-rich diet that altered the 1H-NMRI serum metabolomic profile, improving the oxidative pathway. |
| first_indexed | 2025-10-08T13:51:06Z |
| format | Online |
| id | ojs-article-516 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:51:06Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-5162025-09-26T14:32:30Z Leucine-rich diet alters the (1) H-NMRI serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid Santos, Gabriela Sales dos Marcondes, Maria Cristina Cintra Gomes Manhe, Beatriz Schincariol Silva, Natália Miyaguti Angelo da Oliveira, Sarah Christine Pereira de Cancer-cachexia Maternal nutritional supplementation Serum metabolomic profiling. Cancer-cachexia is a multifactorial chronic disease associated with high inflammation and loss of muscular and adipose tissues and affects 30% of cancer patients. A maternal diet with leucine could alter the inflammatory state and regulate protein synthesis positively, modulating the effects of cachexia. Metabolomic analyses are an important technique to value the effects of cachexia because of the identification of altered metabolites in serum samples and consequently evaluate the impacted metabolic pathways in these patients. Thus, we analysed the regulatory effects of maternal nutritional supplementation with leucine over the serum metabolic profile (using the 1H-NMR analysis) of the adult offspring rats bearing the Walker 256 tumour.The cachexia leads to a characteristic metabolic profile related to an increase in the glycolytic pathway, which is likely modulated by maternal leucine-rich diet that altered the 1H-NMRI serum metabolomic profile, improving the oxidative pathway. Universidade Estadual de Campinas 2019-01-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/516 10.20396/revpibic262018516 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/516/506 Copyright (c) 2019 Gabriela Sales dos Santos, Maria Cristina Cintra Gomes Marcondes http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Santos, Gabriela Sales dos Marcondes, Maria Cristina Cintra Gomes Manhe, Beatriz Schincariol Silva, Natália Miyaguti Angelo da Oliveira, Sarah Christine Pereira de Cancer-cachexia Maternal nutritional supplementation Serum metabolomic profiling. Leucine-rich diet alters the (1) H-NMRI serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid |
| title | Leucine-rich diet alters the (1) H-NMRI serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid |
| title_full | Leucine-rich diet alters the (1) H-NMRI serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid |
| title_fullStr | Leucine-rich diet alters the (1) H-NMRI serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid |
| title_full_unstemmed | Leucine-rich diet alters the (1) H-NMRI serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid |
| title_short | Leucine-rich diet alters the (1) H-NMRI serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid |
| title_sort | leucine-rich diet alters the (1) h-nmri serum metabolomic profile of tumour-bearing adult rats from offspring of mothers supplemented with this branched-chain amino acid |
| topic | Cancer-cachexia Maternal nutritional supplementation Serum metabolomic profiling. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/516 |
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