Nitric oxide releasing collagen membranes for the topical treatment of wounds
Nitric oxide (NO) donor biomaterials have great potential to promote tissue regeneration and healing. Among the materials that can be used for this purpose, collagen has high biocompatibility, low antigenic activity and is already used commercially in the form of membranes with hemostatic action for...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/537 |
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| author | Santos, Giovanna Jardim Vieira P. dos Oliveira, Marcelo Ganzarolli de Picheth, Guilherme Fadel Póvoa, Valéria Araujo, Eliana Pereira de |
| author_facet | Santos, Giovanna Jardim Vieira P. dos Oliveira, Marcelo Ganzarolli de Picheth, Guilherme Fadel Póvoa, Valéria Araujo, Eliana Pereira de |
| author_sort | Santos, Giovanna Jardim Vieira P. dos |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | Nitric oxide (NO) donor biomaterials have great potential to promote tissue regeneration and healing. Among the materials that can be used for this purpose, collagen has high biocompatibility, low antigenic activity and is already used commercially in the form of membranes with hemostatic action for the coating of lesions to favor the regeneration of the injured area. NO is directly involved in angiogenic and proliferative activities, stimulating the tissue repair process in healthy individuals or patients suffering from chronic diseases (e.g. diabetes). The collagen membranes were impregnated with S-nitrosoglutathione (GSNO), a NO donor, through absorption from solution and characterized by vibrational spectroscopy, scanning electron microscopy and dispersive energy spectroscopy. NO release was characterized by chemiluminescence. The kinetics of NO release were shown to be dependent on the hydration degree. In vivo experiments showed that collagen/GSNO membranes accelerate wound healing and increase the expression of cytokines associated with cell proliferation in cicatricial tissue of animals compared with control animals. These results show collagen/GSNO membranes exert an effective wound healing action and have potential to treat chronic ulcers. |
| first_indexed | 2025-10-08T13:51:11Z |
| format | Online |
| id | ojs-article-537 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:51:11Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-5372025-09-26T14:32:30Z Nitric oxide releasing collagen membranes for the topical treatment of wounds Santos, Giovanna Jardim Vieira P. dos Oliveira, Marcelo Ganzarolli de Picheth, Guilherme Fadel Póvoa, Valéria Araujo, Eliana Pereira de Biomaterials Collagen Nitric oxide. Nitric oxide (NO) donor biomaterials have great potential to promote tissue regeneration and healing. Among the materials that can be used for this purpose, collagen has high biocompatibility, low antigenic activity and is already used commercially in the form of membranes with hemostatic action for the coating of lesions to favor the regeneration of the injured area. NO is directly involved in angiogenic and proliferative activities, stimulating the tissue repair process in healthy individuals or patients suffering from chronic diseases (e.g. diabetes). The collagen membranes were impregnated with S-nitrosoglutathione (GSNO), a NO donor, through absorption from solution and characterized by vibrational spectroscopy, scanning electron microscopy and dispersive energy spectroscopy. NO release was characterized by chemiluminescence. The kinetics of NO release were shown to be dependent on the hydration degree. In vivo experiments showed that collagen/GSNO membranes accelerate wound healing and increase the expression of cytokines associated with cell proliferation in cicatricial tissue of animals compared with control animals. These results show collagen/GSNO membranes exert an effective wound healing action and have potential to treat chronic ulcers. Universidade Estadual de Campinas 2019-01-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/537 10.20396/revpibic262018537 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/537/533 Copyright (c) 2019 Giovanna Jardim Vieira P. dos Santos, Marcelo Ganzarolli de Oliveira http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Santos, Giovanna Jardim Vieira P. dos Oliveira, Marcelo Ganzarolli de Picheth, Guilherme Fadel Póvoa, Valéria Araujo, Eliana Pereira de Biomaterials Collagen Nitric oxide. Nitric oxide releasing collagen membranes for the topical treatment of wounds |
| title | Nitric oxide releasing collagen membranes for the topical treatment of wounds |
| title_full | Nitric oxide releasing collagen membranes for the topical treatment of wounds |
| title_fullStr | Nitric oxide releasing collagen membranes for the topical treatment of wounds |
| title_full_unstemmed | Nitric oxide releasing collagen membranes for the topical treatment of wounds |
| title_short | Nitric oxide releasing collagen membranes for the topical treatment of wounds |
| title_sort | nitric oxide releasing collagen membranes for the topical treatment of wounds |
| topic | Biomaterials Collagen Nitric oxide. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/537 |
| work_keys_str_mv | AT santosgiovannajardimvieirapdos nitricoxidereleasingcollagenmembranesforthetopicaltreatmentofwounds AT oliveiramarceloganzarollide nitricoxidereleasingcollagenmembranesforthetopicaltreatmentofwounds AT pichethguilhermefadel nitricoxidereleasingcollagenmembranesforthetopicaltreatmentofwounds AT povoavaleria nitricoxidereleasingcollagenmembranesforthetopicaltreatmentofwounds AT araujoelianapereirade nitricoxidereleasingcollagenmembranesforthetopicaltreatmentofwounds |
