Excipient suitability for freeze-dried protein solutions
This work focused on pre-formulation studies for freeze-dried protein formulations, using albumin as a model protein. Two aminoacids and two sugars were selected as lyoprotectors and studied according a mixture design (simplex-lattice). Sample characterization included total protein content, collaps...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/541 |
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| author | Ferreira, Giovanna Sevilha Nascimento, Laura de Oliveira Geraldes, Danilo Costa |
| author_facet | Ferreira, Giovanna Sevilha Nascimento, Laura de Oliveira Geraldes, Danilo Costa |
| author_sort | Ferreira, Giovanna Sevilha |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | This work focused on pre-formulation studies for freeze-dried protein formulations, using albumin as a model protein. Two aminoacids and two sugars were selected as lyoprotectors and studied according a mixture design (simplex-lattice). Sample characterization included total protein content, collapse temperature and visual inspection. Sugar formulations collapsed, but not aminoacids, which indicate non sugar excipients as the best choice under the studied conditions. |
| first_indexed | 2025-10-08T13:51:12Z |
| format | Online |
| id | ojs-article-541 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:51:12Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-5412025-09-26T14:32:30Z Excipient suitability for freeze-dried protein solutions Ferreira, Giovanna Sevilha Nascimento, Laura de Oliveira Geraldes, Danilo Costa Lyophilization Pre-formulation Excipients. This work focused on pre-formulation studies for freeze-dried protein formulations, using albumin as a model protein. Two aminoacids and two sugars were selected as lyoprotectors and studied according a mixture design (simplex-lattice). Sample characterization included total protein content, collapse temperature and visual inspection. Sugar formulations collapsed, but not aminoacids, which indicate non sugar excipients as the best choice under the studied conditions. Universidade Estadual de Campinas 2019-01-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/541 10.20396/revpibic262018541 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/541/537 Copyright (c) 2019 Giovanna Sevilha Ferreira, Laura de Oliveira Nascimento http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Ferreira, Giovanna Sevilha Nascimento, Laura de Oliveira Geraldes, Danilo Costa Lyophilization Pre-formulation Excipients. Excipient suitability for freeze-dried protein solutions |
| title | Excipient suitability for freeze-dried protein solutions |
| title_full | Excipient suitability for freeze-dried protein solutions |
| title_fullStr | Excipient suitability for freeze-dried protein solutions |
| title_full_unstemmed | Excipient suitability for freeze-dried protein solutions |
| title_short | Excipient suitability for freeze-dried protein solutions |
| title_sort | excipient suitability for freeze-dried protein solutions |
| topic | Lyophilization Pre-formulation Excipients. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/541 |
| work_keys_str_mv | AT ferreiragiovannasevilha excipientsuitabilityforfreezedriedproteinsolutions AT nascimentolauradeoliveira excipientsuitabilityforfreezedriedproteinsolutions AT geraldesdanilocosta excipientsuitabilityforfreezedriedproteinsolutions |
