Production and phisical-chemical analysis of cationics liposomes and STEALTH® types, obtained from microfluidic tecnology for gene therapy application
The research was focused on the production of lipid based vectors for gene therapy by microfluidic devices, particularly carionic liposomes (CL), and their complexation with plasmidic DNA (pDNA). Two types of microfluidic devices were proposed to achieve the goals, a diffusion based microfluidic dev...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/818 |
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| author | Montebugnoli, Leonardo Jose Torre, Lucimara Gaziola de La Eş, Ismail |
| author_facet | Montebugnoli, Leonardo Jose Torre, Lucimara Gaziola de La Eş, Ismail |
| author_sort | Montebugnoli, Leonardo Jose |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | The research was focused on the production of lipid based vectors for gene therapy by microfluidic devices, particularly carionic liposomes (CL), and their complexation with plasmidic DNA (pDNA). Two types of microfluidic devices were proposed to achieve the goals, a diffusion based microfluidic device (D-MD) and a caotic advection based microfluidic device (CA-MD). The research showed that the CA-MD has a better productivity of CL while maintaining good properties. In the complexation studies, the D-MD was capable of make the complexes of genetic materials and liposomes (Lipoplexes). |
| first_indexed | 2025-10-08T13:52:14Z |
| format | Online |
| id | ojs-article-818 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:52:14Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-8182025-09-26T14:32:30Z Production and phisical-chemical analysis of cationics liposomes and STEALTH® types, obtained from microfluidic tecnology for gene therapy application Montebugnoli, Leonardo Jose Torre, Lucimara Gaziola de La Eş, Ismail Microfluidic Liposomes Gene therapy. The research was focused on the production of lipid based vectors for gene therapy by microfluidic devices, particularly carionic liposomes (CL), and their complexation with plasmidic DNA (pDNA). Two types of microfluidic devices were proposed to achieve the goals, a diffusion based microfluidic device (D-MD) and a caotic advection based microfluidic device (CA-MD). The research showed that the CA-MD has a better productivity of CL while maintaining good properties. In the complexation studies, the D-MD was capable of make the complexes of genetic materials and liposomes (Lipoplexes). Universidade Estadual de Campinas 2019-02-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/818 10.20396/revpibic262018818 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/818/888 Copyright (c) 2019 Leonardo Jose Montebugnoli, Lucimara Gaziola de La Torre http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Montebugnoli, Leonardo Jose Torre, Lucimara Gaziola de La Eş, Ismail Microfluidic Liposomes Gene therapy. Production and phisical-chemical analysis of cationics liposomes and STEALTH® types, obtained from microfluidic tecnology for gene therapy application |
| title | Production and phisical-chemical analysis of cationics liposomes and STEALTH® types, obtained from microfluidic tecnology for gene therapy application |
| title_full | Production and phisical-chemical analysis of cationics liposomes and STEALTH® types, obtained from microfluidic tecnology for gene therapy application |
| title_fullStr | Production and phisical-chemical analysis of cationics liposomes and STEALTH® types, obtained from microfluidic tecnology for gene therapy application |
| title_full_unstemmed | Production and phisical-chemical analysis of cationics liposomes and STEALTH® types, obtained from microfluidic tecnology for gene therapy application |
| title_short | Production and phisical-chemical analysis of cationics liposomes and STEALTH® types, obtained from microfluidic tecnology for gene therapy application |
| title_sort | production and phisical-chemical analysis of cationics liposomes and stealth® types, obtained from microfluidic tecnology for gene therapy application |
| topic | Microfluidic Liposomes Gene therapy. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/818 |
| work_keys_str_mv | AT montebugnolileonardojose productionandphisicalchemicalanalysisofcationicsliposomesandstealthtypesobtainedfrommicrofluidictecnologyforgenetherapyapplication AT torrelucimaragazioladela productionandphisicalchemicalanalysisofcationicsliposomesandstealthtypesobtainedfrommicrofluidictecnologyforgenetherapyapplication AT esismail productionandphisicalchemicalanalysisofcationicsliposomesandstealthtypesobtainedfrommicrofluidictecnologyforgenetherapyapplication |
