Investigation of human plasma depletome from patients with schizophrenia
The proteome of blood plasma is an interesting source of biomarkers and a potential way to improve treatment outcomes in psychiatric disorders. Respire that, its wide dynamic concentration range makes reducing its complexity necessary. Thus, in proteomic studies, a few of the most abundant proteins...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/850 |
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| author | Costa, Licia Carla da Silva Souza, Daniel Martins de Rosa, Sheila Garcia Baldasso, Paulo A. Steiner, Johann |
| author_facet | Costa, Licia Carla da Silva Souza, Daniel Martins de Rosa, Sheila Garcia Baldasso, Paulo A. Steiner, Johann |
| author_sort | Costa, Licia Carla da Silva |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | The proteome of blood plasma is an interesting source of biomarkers and a potential way to improve treatment outcomes in psychiatric disorders. Respire that, its wide dynamic concentration range makes reducing its complexity necessary. Thus, in proteomic studies, a few of the most abundant proteins are depleted and normally discarded. This high-abundance fraction, called the depletome, however, is a source of potential biomarkers due to nonspecific bindings with low abundance proteins. In this work, we aimed to characterize the high-abundance fraction using a shotgun mass spectrometry approach. These proteins show the importance of studying depletome proteins in the quest for biomarkers. |
| first_indexed | 2025-10-08T13:52:21Z |
| format | Online |
| id | ojs-article-850 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:52:21Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-8502025-09-26T14:32:30Z Investigation of human plasma depletome from patients with schizophrenia Costa, Licia Carla da Silva Souza, Daniel Martins de Rosa, Sheila Garcia Baldasso, Paulo A. Steiner, Johann Proteomics Schizophrenia Biomarkers. The proteome of blood plasma is an interesting source of biomarkers and a potential way to improve treatment outcomes in psychiatric disorders. Respire that, its wide dynamic concentration range makes reducing its complexity necessary. Thus, in proteomic studies, a few of the most abundant proteins are depleted and normally discarded. This high-abundance fraction, called the depletome, however, is a source of potential biomarkers due to nonspecific bindings with low abundance proteins. In this work, we aimed to characterize the high-abundance fraction using a shotgun mass spectrometry approach. These proteins show the importance of studying depletome proteins in the quest for biomarkers. Universidade Estadual de Campinas 2019-02-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/850 10.20396/revpibic262018850 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/850/920 Copyright (c) 2019 Licia Carla da Silva Costa, Daniel Martins de Souza http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Costa, Licia Carla da Silva Souza, Daniel Martins de Rosa, Sheila Garcia Baldasso, Paulo A. Steiner, Johann Proteomics Schizophrenia Biomarkers. Investigation of human plasma depletome from patients with schizophrenia |
| title | Investigation of human plasma depletome from patients with schizophrenia |
| title_full | Investigation of human plasma depletome from patients with schizophrenia |
| title_fullStr | Investigation of human plasma depletome from patients with schizophrenia |
| title_full_unstemmed | Investigation of human plasma depletome from patients with schizophrenia |
| title_short | Investigation of human plasma depletome from patients with schizophrenia |
| title_sort | investigation of human plasma depletome from patients with schizophrenia |
| topic | Proteomics Schizophrenia Biomarkers. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/850 |
| work_keys_str_mv | AT costaliciacarladasilva investigationofhumanplasmadepletomefrompatientswithschizophrenia AT souzadanielmartinsde investigationofhumanplasmadepletomefrompatientswithschizophrenia AT rosasheilagarcia investigationofhumanplasmadepletomefrompatientswithschizophrenia AT baldassopauloa investigationofhumanplasmadepletomefrompatientswithschizophrenia AT steinerjohann investigationofhumanplasmadepletomefrompatientswithschizophrenia |
