How do MK-801 and risperidone modulate the proteome of human oligodendrocytes?
Schizophrenia is a complex neuropsychiatric disorder developed by genetic and environmental factors. The treatment is based on antipsychotics, such as risperidone. Some of illness symptoms has been mimic by MK-801, a non-competitive antagonist of glutamate NMDA receptor. Proteome evidences have been...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/856 |
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| author | Silva, Livia Ramos da Souza, Daniel Martins de Teles, Caroline Brandão |
| author_facet | Silva, Livia Ramos da Souza, Daniel Martins de Teles, Caroline Brandão |
| author_sort | Silva, Livia Ramos da |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | Schizophrenia is a complex neuropsychiatric disorder developed by genetic and environmental factors. The treatment is based on antipsychotics, such as risperidone. Some of illness symptoms has been mimic by MK-801, a non-competitive antagonist of glutamate NMDA receptor. Proteome evidences have been shown disturbances in oligodendrocytes metabolism of schizophrenia patients, mainly in energy metabolism. The aim of this study is to characterize the proteome of a human oligodendrocyte cell line treated with MK-801, risperidone and the co-treatment, in order to shed light about the interactions between schizophrenia and the antipsychotic drug risperidone. |
| first_indexed | 2025-10-08T13:52:22Z |
| format | Online |
| id | ojs-article-856 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:52:22Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-8562025-09-26T14:32:30Z How do MK-801 and risperidone modulate the proteome of human oligodendrocytes? Silva, Livia Ramos da Souza, Daniel Martins de Teles, Caroline Brandão Schizophrenia NMDA receptor Risperidone. Schizophrenia is a complex neuropsychiatric disorder developed by genetic and environmental factors. The treatment is based on antipsychotics, such as risperidone. Some of illness symptoms has been mimic by MK-801, a non-competitive antagonist of glutamate NMDA receptor. Proteome evidences have been shown disturbances in oligodendrocytes metabolism of schizophrenia patients, mainly in energy metabolism. The aim of this study is to characterize the proteome of a human oligodendrocyte cell line treated with MK-801, risperidone and the co-treatment, in order to shed light about the interactions between schizophrenia and the antipsychotic drug risperidone. Universidade Estadual de Campinas 2019-02-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/856 10.20396/revpibic262018856 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/856/926 Copyright (c) 2019 Livia Ramos da Silva, Daniel Martins de Souza http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Silva, Livia Ramos da Souza, Daniel Martins de Teles, Caroline Brandão Schizophrenia NMDA receptor Risperidone. How do MK-801 and risperidone modulate the proteome of human oligodendrocytes? |
| title | How do MK-801 and risperidone modulate the proteome of human oligodendrocytes? |
| title_full | How do MK-801 and risperidone modulate the proteome of human oligodendrocytes? |
| title_fullStr | How do MK-801 and risperidone modulate the proteome of human oligodendrocytes? |
| title_full_unstemmed | How do MK-801 and risperidone modulate the proteome of human oligodendrocytes? |
| title_short | How do MK-801 and risperidone modulate the proteome of human oligodendrocytes? |
| title_sort | how do mk-801 and risperidone modulate the proteome of human oligodendrocytes? |
| topic | Schizophrenia NMDA receptor Risperidone. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/856 |
| work_keys_str_mv | AT silvaliviaramosda howdomk801andrisperidonemodulatetheproteomeofhumanoligodendrocytes AT souzadanielmartinsde howdomk801andrisperidonemodulatetheproteomeofhumanoligodendrocytes AT telescarolinebrandao howdomk801andrisperidonemodulatetheproteomeofhumanoligodendrocytes |
