Association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men
High cardiorespiratory fitness levels (CRF) are strongly associated with reduction of risk of all-cause and cardiovascular disease mortality. CRF can be assessed by maximal oxygen uptake (VO2MAX) or maximal power output (MPO). Skeletal muscle is the main organ responsible for peripheral adaptations...
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| Formato: | Online |
| Lenguaje: | inglés |
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Universidade Estadual de Campinas
2019
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| Acceso en línea: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/882 |
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| _version_ | 1864358622216060928 |
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| author | Silva, Lucas de Marchi Mikahil, Mara Patricia Tarina Chacon Castro, Alex Duft, Renata Garbellini Ferreira, Marina Lívia Venturini Andrade, André Luís Lugnani de Cavaglieri, Cláudia Regina |
| author_facet | Silva, Lucas de Marchi Mikahil, Mara Patricia Tarina Chacon Castro, Alex Duft, Renata Garbellini Ferreira, Marina Lívia Venturini Andrade, André Luís Lugnani de Cavaglieri, Cláudia Regina |
| author_sort | Silva, Lucas de Marchi |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | High cardiorespiratory fitness levels (CRF) are strongly associated with reduction of risk of all-cause and cardiovascular disease mortality. CRF can be assessed by maximal oxygen uptake (VO2MAX) or maximal power output (MPO). Skeletal muscle is the main organ responsible for peripheral adaptations related to CRF improvement. In this sense, metabolomics has been pointing out as a potential tool to identify muscular metabolic signature in response to exercise and different phenotypes. Therefore, this study aimed to investigate metabolites in human skeletal muscle associated with CRF. Participated in this study 70 sedentary young men (18-30 years old). Vastus lateralis muscle biopsies were collected at fasting state (12 h). After 72 h, CRF was assessed by MPO, obtained during a maximal incremental test performed until voluntary exhaustion in cycle ergometer, followed by re-test 48 h later. Skeletal muscle samples were analysed through metabolomics (H1 NMR spectroscopy). Associations of baseline metabolites with MPO were explored via three analytical strategies: (1) correlations with gains in MPO; (2) significant difference between groups of and Low CRF and High CRF; and (3) metabolite contribution to significant pathways related to MPO. The significance level was P < 0.01 or false discovery rate of 0.1. From 70 identified metabolites, only Formate and NADP+ were supported by the three levels of evidence. Intrinsic CRF levels are associated with higher baseline metabolities. |
| first_indexed | 2025-10-08T13:52:28Z |
| format | Online |
| id | ojs-article-882 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:52:28Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-8822025-09-26T14:32:30Z Association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men Silva, Lucas de Marchi Mikahil, Mara Patricia Tarina Chacon Castro, Alex Duft, Renata Garbellini Ferreira, Marina Lívia Venturini Andrade, André Luís Lugnani de Cavaglieri, Cláudia Regina Maximal power output Metabolomics Skeletal muscle. High cardiorespiratory fitness levels (CRF) are strongly associated with reduction of risk of all-cause and cardiovascular disease mortality. CRF can be assessed by maximal oxygen uptake (VO2MAX) or maximal power output (MPO). Skeletal muscle is the main organ responsible for peripheral adaptations related to CRF improvement. In this sense, metabolomics has been pointing out as a potential tool to identify muscular metabolic signature in response to exercise and different phenotypes. Therefore, this study aimed to investigate metabolites in human skeletal muscle associated with CRF. Participated in this study 70 sedentary young men (18-30 years old). Vastus lateralis muscle biopsies were collected at fasting state (12 h). After 72 h, CRF was assessed by MPO, obtained during a maximal incremental test performed until voluntary exhaustion in cycle ergometer, followed by re-test 48 h later. Skeletal muscle samples were analysed through metabolomics (H1 NMR spectroscopy). Associations of baseline metabolites with MPO were explored via three analytical strategies: (1) correlations with gains in MPO; (2) significant difference between groups of and Low CRF and High CRF; and (3) metabolite contribution to significant pathways related to MPO. The significance level was P < 0.01 or false discovery rate of 0.1. From 70 identified metabolites, only Formate and NADP+ were supported by the three levels of evidence. Intrinsic CRF levels are associated with higher baseline metabolities. Universidade Estadual de Campinas 2019-02-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/882 10.20396/revpibic262018882 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/882/952 Copyright (c) 2019 Lucas de Marchi Silva, Mara Patricia Tarina Chacon Mikahil http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Silva, Lucas de Marchi Mikahil, Mara Patricia Tarina Chacon Castro, Alex Duft, Renata Garbellini Ferreira, Marina Lívia Venturini Andrade, André Luís Lugnani de Cavaglieri, Cláudia Regina Maximal power output Metabolomics Skeletal muscle. Association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men |
| title | Association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men |
| title_full | Association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men |
| title_fullStr | Association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men |
| title_full_unstemmed | Association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men |
| title_short | Association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men |
| title_sort | association between skeletal musce metabolomics profile and cardiorespiratory fitness in young men |
| topic | Maximal power output Metabolomics Skeletal muscle. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/882 |
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