The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease
Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most prevalent disorders in the elderly population. Studies suggest that people with T2DM have higher risk of developing AD. Likewise, AD brains presents Insulin resistance resulting in low capacity of glucose uptake. T...
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| Format: | Online |
| Language: | English |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/908 |
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| author | Zangerolamo, Lucas Sampaio, Helena Cristina de Lima Barbosa Vettorazzi, Jean Franciesco Solon, Carina Soares, Gabriela Moreira Enchn, Raquel Crespo Carneiro, Everardo Magalhães Velloso, Licio Augusto Boschero, Antonio Carlos |
| author_facet | Zangerolamo, Lucas Sampaio, Helena Cristina de Lima Barbosa Vettorazzi, Jean Franciesco Solon, Carina Soares, Gabriela Moreira Enchn, Raquel Crespo Carneiro, Everardo Magalhães Velloso, Licio Augusto Boschero, Antonio Carlos |
| author_sort | Zangerolamo, Lucas |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp |
| description | Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most prevalent disorders in the elderly population. Studies suggest that people with T2DM have higher risk of developing AD. Likewise, AD brains presents Insulin resistance resulting in low capacity of glucose uptake. There is a growing evidence that insulin resistance and downstream abnormalities in the insulin signaling pathway are present in the AD brain and contribute to the development of cognitive dysfunction. Here we reported that C57BL/6 mice submitted to intracerebroventricular injection of streptozotocin, model of AD, and treated during 10 days with the bile acid TUDCA presented reduced accumulation of A? oligomer in the hippocampus and higher insulin secretion and glucose tolerance, besides improvement in memory test, suggesting that TUDCA treatment interferes with glucose-insulin homeostasis in brain and consequently attenuates AD. |
| first_indexed | 2025-10-08T13:52:33Z |
| format | Online |
| id | ojs-article-908 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | eng |
| last_indexed | 2025-10-08T13:52:33Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-9082025-09-26T14:32:30Z The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease Zangerolamo, Lucas Sampaio, Helena Cristina de Lima Barbosa Vettorazzi, Jean Franciesco Solon, Carina Soares, Gabriela Moreira Enchn, Raquel Crespo Carneiro, Everardo Magalhães Velloso, Licio Augusto Boschero, Antonio Carlos TUDCA Glucose homeostasis Alzheimer. Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most prevalent disorders in the elderly population. Studies suggest that people with T2DM have higher risk of developing AD. Likewise, AD brains presents Insulin resistance resulting in low capacity of glucose uptake. There is a growing evidence that insulin resistance and downstream abnormalities in the insulin signaling pathway are present in the AD brain and contribute to the development of cognitive dysfunction. Here we reported that C57BL/6 mice submitted to intracerebroventricular injection of streptozotocin, model of AD, and treated during 10 days with the bile acid TUDCA presented reduced accumulation of A? oligomer in the hippocampus and higher insulin secretion and glucose tolerance, besides improvement in memory test, suggesting that TUDCA treatment interferes with glucose-insulin homeostasis in brain and consequently attenuates AD. Universidade Estadual de Campinas 2019-02-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/908 10.20396/revpibic262018908 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 26 (2018): Congresso de Iniciação Científica Unicamp 2596-1969 eng https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/908/978 Copyright (c) 2019 Lucas Zangerolamo, Helena Cristina de Lima Barbosa Sampaio http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Zangerolamo, Lucas Sampaio, Helena Cristina de Lima Barbosa Vettorazzi, Jean Franciesco Solon, Carina Soares, Gabriela Moreira Enchn, Raquel Crespo Carneiro, Everardo Magalhães Velloso, Licio Augusto Boschero, Antonio Carlos TUDCA Glucose homeostasis Alzheimer. The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease |
| title | The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease |
| title_full | The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease |
| title_fullStr | The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease |
| title_full_unstemmed | The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease |
| title_short | The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease |
| title_sort | bile acid tudca improves glucose homeostasis through increase of insulin levels in mice with alzheimer's disease |
| topic | TUDCA Glucose homeostasis Alzheimer. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/908 |
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