Metabolic syndrome biomarker is associated to higher severity of breast cancer
Obesity, which is related to various comorbidities, including the metabolic syndrome (MS), has also been associated to the breast cancer's development and progress, which is the most frequent cancer among women. The MS has been associated to the risk, for both development and the worst prognosi...
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| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | Portuguese |
| Published: |
Universidade Estadual de Campinas (UNICAMP)
2016
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| Subjects: | |
| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9294 |
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| Summary: | Obesity, which is related to various comorbidities, including the metabolic syndrome (MS), has also been associated to the breast cancer's development and progress, which is the most frequent cancer among women. The MS has been associated to the risk, for both development and the worst prognosis of this type of cancer. Among the various adipokines secreted by the adipose tissue, is the adipocyte oily acids carrier protein (A-FABP), which, in obesity, is present in higher concentrations and has been considered as a MS marker. Most recently, this adipokine has been associated to carcinogenesis and worst prognosis of various tumors, including the breast tumors. With the purpose of assessing the A-FABP association to MS and the clinical-pathological characteristics of breast cancer, 152 patients cared on CAISM/UNICAMP were classified in three groups: non-obese (NO), overweight/obesity (SP/O) and overweight/obesity with metabolic syndrome (SP/O-SM); and they had serum A-FABP concentrations determined by ELISA technique. Higher A-FABP concentrations were detected on the SP/O-SM group, suggesting the A-FABP role as a MS biomarker, also in patients with breast cancer. Besides that, this adipokine demonstrated associations to worst prognosis factors, on both SP/O-SM and NO groups. As these associations were kept after variables adjustments (body mass index, waist circumference and menopausal age/status, the results suggest A-FABP relationship with higher breast cancer severity, regardless of obesity and encourage a deeper study on these relationships. |
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| ISSN: | 2525-5398 |
