Metabolic syndrome biomarker is associated to higher severity of breast cancer
Obesity, which is related to various comorbidities, including the metabolic syndrome (MS), has also been associated to the breast cancer's development and progress, which is the most frequent cancer among women. The MS has been associated to the risk, for both development and the worst prognosi...
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas (UNICAMP)
2016
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9294 |
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| author | Nascimento, Higor Campos Cralcev, Christopher Santana, Aline Barros Faria, Eliana Cotta Gurgel, Maria Salete Costa Mazon, Sílvia de Barros |
| author_facet | Nascimento, Higor Campos Cralcev, Christopher Santana, Aline Barros Faria, Eliana Cotta Gurgel, Maria Salete Costa Mazon, Sílvia de Barros |
| author_sort | Nascimento, Higor Campos |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Resumo dos trabalhos do SIMTEC Simpósio dos Profissionais da UNICAMP; v. 6 (2016): Temática: UNICAMP 50 ANOS - Memórias, Experiências e Trajetórias profissionais; 117-117 |
| description | Obesity, which is related to various comorbidities, including the metabolic syndrome (MS), has also been associated to the breast cancer's development and progress, which is the most frequent cancer among women. The MS has been associated to the risk, for both development and the worst prognosis of this type of cancer. Among the various adipokines secreted by the adipose tissue, is the adipocyte oily acids carrier protein (A-FABP), which, in obesity, is present in higher concentrations and has been considered as a MS marker. Most recently, this adipokine has been associated to carcinogenesis and worst prognosis of various tumors, including the breast tumors. With the purpose of assessing the A-FABP association to MS and the clinical-pathological characteristics of breast cancer, 152 patients cared on CAISM/UNICAMP were classified in three groups: non-obese (NO), overweight/obesity (SP/O) and overweight/obesity with metabolic syndrome (SP/O-SM); and they had serum A-FABP concentrations determined by ELISA technique. Higher A-FABP concentrations were detected on the SP/O-SM group, suggesting the A-FABP role as a MS biomarker, also in patients with breast cancer. Besides that, this adipokine demonstrated associations to worst prognosis factors, on both SP/O-SM and NO groups. As these associations were kept after variables adjustments (body mass index, waist circumference and menopausal age/status, the results suggest A-FABP relationship with higher breast cancer severity, regardless of obesity and encourage a deeper study on these relationships. |
| first_indexed | 2025-10-08T14:03:49Z |
| format | Online |
| id | ojs-article-9294 |
| institution | Universidade Estadual de Campinas |
| issn | 2525-5398 |
| language | por |
| last_indexed | 2026-09-16T21:01:29Z |
| publishDate | 2016 |
| publisher | Universidade Estadual de Campinas (UNICAMP) |
| record_format | ojs |
| spelling | ojs-article-92942026-09-16T11:35:21Z Metabolic syndrome biomarker is associated to higher severity of breast cancer Biomarcador de síndrome metabólica está associado a maior gravidade do câncer mamário Nascimento, Higor Campos Cralcev, Christopher Santana, Aline Barros Faria, Eliana Cotta Gurgel, Maria Salete Costa Mazon, Sílvia de Barros Neoplasias da mama. Obesidade. Síndrome metabólica. Adipocinas. A-fabp. Obesity, which is related to various comorbidities, including the metabolic syndrome (MS), has also been associated to the breast cancer's development and progress, which is the most frequent cancer among women. The MS has been associated to the risk, for both development and the worst prognosis of this type of cancer. Among the various adipokines secreted by the adipose tissue, is the adipocyte oily acids carrier protein (A-FABP), which, in obesity, is present in higher concentrations and has been considered as a MS marker. Most recently, this adipokine has been associated to carcinogenesis and worst prognosis of various tumors, including the breast tumors. With the purpose of assessing the A-FABP association to MS and the clinical-pathological characteristics of breast cancer, 152 patients cared on CAISM/UNICAMP were classified in three groups: non-obese (NO), overweight/obesity (SP/O) and overweight/obesity with metabolic syndrome (SP/O-SM); and they had serum A-FABP concentrations determined by ELISA technique. Higher A-FABP concentrations were detected on the SP/O-SM group, suggesting the A-FABP role as a MS biomarker, also in patients with breast cancer. Besides that, this adipokine demonstrated associations to worst prognosis factors, on both SP/O-SM and NO groups. As these associations were kept after variables adjustments (body mass index, waist circumference and menopausal age/status, the results suggest A-FABP relationship with higher breast cancer severity, regardless of obesity and encourage a deeper study on these relationships. A obesidade, que está relacionada a diversas comorbidades incluindo a síndrome metabólica (SM), também tem sido associada ao desenvolvimento e progressão do câncer mamário, que é o tipo de câncer mais frequente entre as mulheres. A SM tem sido associada ao risco, tanto para o desenvolvimento como para o pior prognóstico desse tipo de câncer. Dentre as diversas adipocinas secretadas pelo tecido adiposo encontra-se a proteína transportadora de ácidos graxos de adipócitos (A-FABP), que na obesidade está presente em concentrações mais elevadas e tem sido considerada um marcador de SM. Mais recentemente esta adipocina tem sido associada à carcinogênese e a piores prognósticos de vários tumores, incluindo os de mama. Com o objetivo de avaliar a associação da A-FABP com a SM e as características clinicopatológicas do câncer de mama, 152 pacientes atendidas no CAISM/UNICAMP foram classificadas em três grupos: não obesas (NO), sobrepeso/obesidade (SP/O) e sobrepeso/obesidade com síndrome metabólica (SP/O-SM); e tiveram as concentrações séricas de A-FABP determinadas pela técnica de ELISA. Concentrações mais elevadas de A-FABP foram detectadas no grupo SP/O-SM, sugerindo o papel da A-FABP como um biomarcador da SM, também em pacientes com câncer mamário. Além disso, esta adipocina mostrou associações com fatores de pior prognóstico tanto no grupo SP/O-SM, como no grupo NO. Como essas associações foram mantidas após ajustes das variáveis: índice de massa corpórea, circunferência abdominal e idade/estado menopausal, os resultados sugerem relação da A-FABP com maior gravidade do câncer mamário, independentemente de obesidade e incentivam o estudo mais aprofundado dessas relações. Universidade Estadual de Campinas (UNICAMP) 2016-10-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Análise lógica Analytical Research application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9294 10.20396/simtec.v6.2016.9294 Resumo dos trabalhos do SIMTEC Simpósio dos Profissionais da UNICAMP; v. 6 (2016): Temática: UNICAMP 50 ANOS - Memórias, Experiências e Trajetórias profissionais; 117-117 2525-5398 por https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9294/12589 Copyright (c) 2016 Higor Campos Nascimento, Christopher Cralcev, Aline Barros Santana, Eliana Cotta Faria, Maria Salete Costa Gurgel, Sílvia de Barros Mazon https://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Nascimento, Higor Campos Cralcev, Christopher Santana, Aline Barros Faria, Eliana Cotta Gurgel, Maria Salete Costa Mazon, Sílvia de Barros Neoplasias da mama. Obesidade. Síndrome metabólica. Adipocinas. A-fabp. Metabolic syndrome biomarker is associated to higher severity of breast cancer |
| title | Metabolic syndrome biomarker is associated to higher severity of breast cancer |
| title_full | Metabolic syndrome biomarker is associated to higher severity of breast cancer |
| title_fullStr | Metabolic syndrome biomarker is associated to higher severity of breast cancer |
| title_full_unstemmed | Metabolic syndrome biomarker is associated to higher severity of breast cancer |
| title_short | Metabolic syndrome biomarker is associated to higher severity of breast cancer |
| title_sort | metabolic syndrome biomarker is associated to higher severity of breast cancer |
| topic | Neoplasias da mama. Obesidade. Síndrome metabólica. Adipocinas. A-fabp. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9294 |
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