The effect of the environmental enrichment to genetically modified mice's wellness.
The great human knowledge progress in human and veterinary medicine and the use of laboratory animals in scientific researches, resulted in a need to implement new techniques that would favor the laboratory animals' wellness. In this experiment, genetically modified mice from the STOCK Hbatm1Pa...
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Universidade Estadual de Campinas (UNICAMP)
2016
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| Acceso en línea: | https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9301 |
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| author | Silva, Elson André Campos, Alex Vinícius Alves, Delma Pegolo Alves, Edivana Aparecida Vespa Lopes, Marina |
| author_facet | Silva, Elson André Campos, Alex Vinícius Alves, Delma Pegolo Alves, Edivana Aparecida Vespa Lopes, Marina |
| author_sort | Silva, Elson André |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Resumo dos trabalhos do SIMTEC Simpósio dos Profissionais da UNICAMP; v. 6 (2016): Temática: UNICAMP 50 ANOS - Memórias, Experiências e Trajetórias profissionais; 115-115 |
| description | The great human knowledge progress in human and veterinary medicine and the use of laboratory animals in scientific researches, resulted in a need to implement new techniques that would favor the laboratory animals' wellness. In this experiment, genetically modified mice from the STOCK Hbatm1Paz Hbbtm1Tow Tg (HBA-HBBs) 41Paz/J lineage were used, divided in Control group and Super Environmental Enrichment (EE) group, with 5 matrices in each group. During the whole experiment, the S.P.F (Specific Pathogen Free) mice matrices were kept in two isolating units in a refrigerated environment, with temperature 21ºC±3, 12h/12h photoperiod in the Gnotobiosis department from CEMIB/UNICAMP. All materials and inputs, including EEs, were sterilized inside autoclave cylinders at 125 º C for 30 minutes, connected, and transferred to the isolating units. 120 observation hours were carried out and with weekly assessment for 60 days of animal reproductive performance (interbirths, reproduction ability rate, mortality rate, weight curve for babies and matrices). The results obtained shown improvement on the locomotor and exploratory activity of the group with EE; however, both groups presented the same reproductive performance. The use of environmental enrichment in lineages of genetically modified mice was efficient concerning the animal wellness. |
| first_indexed | 2025-10-08T14:03:50Z |
| format | Online |
| id | ojs-article-9301 |
| institution | Universidade Estadual de Campinas |
| issn | 2525-5398 |
| language | por |
| last_indexed | 2026-09-18T21:01:10Z |
| publishDate | 2016 |
| publisher | Universidade Estadual de Campinas (UNICAMP) |
| record_format | ojs |
| spelling | ojs-article-93012026-09-18T11:21:00Z The effect of the environmental enrichment to genetically modified mice's wellness. O efeito do enriquecimento ambiental para o bem-estar de camundongos transgênicos Silva, Elson André Campos, Alex Vinícius Alves, Delma Pegolo Alves, Edivana Aparecida Vespa Lopes, Marina Enriquecimento ambiental(ea). Bem-estar. Camundongo transgênico. The great human knowledge progress in human and veterinary medicine and the use of laboratory animals in scientific researches, resulted in a need to implement new techniques that would favor the laboratory animals' wellness. In this experiment, genetically modified mice from the STOCK Hbatm1Paz Hbbtm1Tow Tg (HBA-HBBs) 41Paz/J lineage were used, divided in Control group and Super Environmental Enrichment (EE) group, with 5 matrices in each group. During the whole experiment, the S.P.F (Specific Pathogen Free) mice matrices were kept in two isolating units in a refrigerated environment, with temperature 21ºC±3, 12h/12h photoperiod in the Gnotobiosis department from CEMIB/UNICAMP. All materials and inputs, including EEs, were sterilized inside autoclave cylinders at 125 º C for 30 minutes, connected, and transferred to the isolating units. 120 observation hours were carried out and with weekly assessment for 60 days of animal reproductive performance (interbirths, reproduction ability rate, mortality rate, weight curve for babies and matrices). The results obtained shown improvement on the locomotor and exploratory activity of the group with EE; however, both groups presented the same reproductive performance. The use of environmental enrichment in lineages of genetically modified mice was efficient concerning the animal wellness. O grande avanço do conhecimento humano na medicina humana e veterinária e a utilização de animais de laboratório em pesquisas científicas, fez com que houvesse a necessidade de implementação de novas técnicas que favorecessem assim o bem estar dos animais de laboratório. Neste experimento foram utilizados camundongos transgênicos da linhagem STOCK Hbatm1Paz Hbbtm1Tow Tg (HBA-HBBs) 41Paz/J, divididos em grupo Controle e grupo de Super Enriquecimento Ambiental (EA) com 5 matrizes em cada grupo. Durante todo o experimento, as matrizes de camundongos S.P.F (Specific Pathogen Free) foram mantidas em duas unidades isoladoras em ambiente climatizado com temperatura 21ºC±3, fotoperíodo 12h/12h na área de Gnotobiologia do CEMIB/UNICAMP. Todos os materiais e insumos, incluindo os EAs foram esterilizados dentro de cilindros em autoclaves a 125ºC por 30 minutos e conectados e transferidos para as unidades isoladoras. Foram realizadas 120 horas de observação e com avaliação semanal por 60 dias da performace reprodutiva dos animais (inter-partos, taxa de reprodutividade, taxa de mortalidade, curva de peso dos filhotes e das matrizes). Os resultados obtidos demonstraram melhoria da atividade locomotora e exploratória do grupo com EA, porém os 2 grupos apresentaram a mesma performance reprodutiva. O uso de enriquecimento ambiental em linhagens de camundongos transgênicos foi eficiente no que se diz respeito ao bem-estar dos animais. Universidade Estadual de Campinas (UNICAMP) 2016-10-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Análise lógica Analytical Research application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9301 10.20396/simtec.v6.2016.9301 Resumo dos trabalhos do SIMTEC Simpósio dos Profissionais da UNICAMP; v. 6 (2016): Temática: UNICAMP 50 ANOS - Memórias, Experiências e Trajetórias profissionais; 115-115 2525-5398 por https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9301/12594 Copyright (c) 2016 Elson André Silva, Alex Vinícius Campos, Delma Pegolo Alves, Edivana Aparecida Vespa Alves, Marina Lopes https://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Silva, Elson André Campos, Alex Vinícius Alves, Delma Pegolo Alves, Edivana Aparecida Vespa Lopes, Marina Enriquecimento ambiental(ea). Bem-estar. Camundongo transgênico. The effect of the environmental enrichment to genetically modified mice's wellness. |
| title | The effect of the environmental enrichment to genetically modified mice's wellness. |
| title_full | The effect of the environmental enrichment to genetically modified mice's wellness. |
| title_fullStr | The effect of the environmental enrichment to genetically modified mice's wellness. |
| title_full_unstemmed | The effect of the environmental enrichment to genetically modified mice's wellness. |
| title_short | The effect of the environmental enrichment to genetically modified mice's wellness. |
| title_sort | effect of the environmental enrichment to genetically modified mice's wellness. |
| topic | Enriquecimento ambiental(ea). Bem-estar. Camundongo transgênico. |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/simtec/article/view/9301 |
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