Study of tumour global DNA methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats
Cancer-cachexia is a multifactorial syndrome characterised by negative protein balance, associated with alterations in Akt/mTOR (protein synthesis) and Ubiquitin-proteasome (protein degradation) pathways. Maternal supplementation with the amino acid leucine during pregnancy and lactation can amelior...
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| Format: | Online |
| Language: | Portuguese |
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Universidade Estadual de Campinas
2019
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| Online Access: | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2948 |
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| author | Manhe, Beatriz Marcondes, Maria Oliveira, Sarah de Miyaguti, Natália Geraldo, Murilo Gomes-Marcondes, Maria |
| author_facet | Manhe, Beatriz Marcondes, Maria Oliveira, Sarah de Miyaguti, Natália Geraldo, Murilo Gomes-Marcondes, Maria |
| author_sort | Manhe, Beatriz |
| collection | Portal de Eventos Científicos da UNICAMP |
| container_reference | Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 |
| description | Cancer-cachexia is a multifactorial syndrome characterised by negative protein balance, associated with alterations in Akt/mTOR (protein synthesis) and Ubiquitin-proteasome (protein degradation) pathways. Maternal supplementation with the amino acid leucine during pregnancy and lactation can ameliorate muscle loss in adult offspring tumour-bearing rats. The mTOR pathway proteins expression is altered in this situation, and these modifications may be associated with epigenetic modifications. Therefore, in this study, we aimed to analyse the methylation in CpG islands of Pik3r6, mTOR and RPS6KB1 promoters in muscle and the global DNA methylation in tumour tissue in order to investigate the possible epigenetic modifications provided by the maternal diet in the offspring. |
| first_indexed | 2025-10-08T13:59:06Z |
| format | Online |
| id | ojs-article-2948 |
| institution | Universidade Estadual de Campinas |
| issn | 2596-1969 |
| language | por |
| last_indexed | 2025-10-08T13:59:06Z |
| publishDate | 2019 |
| publisher | Universidade Estadual de Campinas |
| record_format | ojs |
| spelling | ojs-article-29482025-09-26T14:39:16Z Study of tumour global DNA methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats Manhe, Beatriz Marcondes, Maria Oliveira, Sarah de Miyaguti, Natália Geraldo, Murilo Gomes-Marcondes, Maria Cancer-cachexia Leucine Epigenetics Cancer-cachexia is a multifactorial syndrome characterised by negative protein balance, associated with alterations in Akt/mTOR (protein synthesis) and Ubiquitin-proteasome (protein degradation) pathways. Maternal supplementation with the amino acid leucine during pregnancy and lactation can ameliorate muscle loss in adult offspring tumour-bearing rats. The mTOR pathway proteins expression is altered in this situation, and these modifications may be associated with epigenetic modifications. Therefore, in this study, we aimed to analyse the methylation in CpG islands of Pik3r6, mTOR and RPS6KB1 promoters in muscle and the global DNA methylation in tumour tissue in order to investigate the possible epigenetic modifications provided by the maternal diet in the offspring. Universidade Estadual de Campinas 2019-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo de convidado application/pdf https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2948 10.20396/revpibic2720192948 Revista dos Trabalhos de Iniciação Científica da UNICAMP; n. 27 (2019): Congresso de Iniciação Científica UNICAMP; 1-1 2596-1969 por https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2948/2942 Copyright (c) 2019 Revista dos Trabalhos de Iniciação Científica da UNICAMP http://creativecommons.org/licenses/by/4.0 |
| spellingShingle | Manhe, Beatriz Marcondes, Maria Oliveira, Sarah de Miyaguti, Natália Geraldo, Murilo Gomes-Marcondes, Maria Cancer-cachexia Leucine Epigenetics Study of tumour global DNA methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats |
| title | Study of tumour global DNA methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats |
| title_full | Study of tumour global DNA methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats |
| title_fullStr | Study of tumour global DNA methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats |
| title_full_unstemmed | Study of tumour global DNA methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats |
| title_short | Study of tumour global DNA methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats |
| title_sort | study of tumour global dna methylation and mtor pathway genes promoters methylation in maternally leucine-supplemented tumour-bearing adult rats |
| topic | Cancer-cachexia Leucine Epigenetics |
| url | https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2948 |
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